15438-67-2

Usage

Uses

Used in Pharmaceutical Industry:
Propanamide, 3-methoxyis used as a building block for the synthesis of various drugs and pharmaceutical compounds due to its versatile chemical structure and compatibility with different chemical reactions.
Used in Chemical Reactions:
Propanamide, 3-methoxyis used as a precursor for the production of other organic compounds, leveraging its unique structure and reactivity in various chemical processes.
Used in Pharmaceutical Formulations:
Propanamide, 3-methoxyis used as an important ingredient in many pharmaceutical formulations, contributing to the solubility and stability of the final products in different solvents.

Upstream product

• 110-67-8 3-Methoxypropionitrile 
• 67-56-1 methanol 
• 79-06-1 2-propenamide 
• 3852-09-3 methyl 3-methoxypropionate 

Downstream Products

• 110-67-8 3-Methoxypropionitrile 
• 79-06-1 2-propenamide 
• 1506-53-2 N-dodecanoylacrylamide 
• 74302-19-5 N-(3-dimethylaminopropyl)-3-methoxypropionamide 
• 3066-72-6 N-cyclohexyl acrylamide 
• 13304-62-6 N-benzylacrylamide 
• 107-13-1 acrylonitrile 

Relevant academic research and scientific papers

Formation of a New, Strongly Basic Nitrogen Anion by Metal Oxide Modification

Development of new hybrid materials having unique and unprecedented catalytic properties is a challenge for chemists, and heterogeneous-homogeneous hybrid catalysts have attracted much attention because of the preferable and exceptional properties that are highly expected to result from combination of the components. Base catalysts are widely used in organic synthesis as key materials, and a new class of base catalysts has made a large impact from academic and industrial viewpoints. Here, a principle for creating a new strong base by hybridization of homogeneous and heterogeneous components is presented. It is based on the modification of organic compounds with metal oxides by using the acid-base property of metal oxides. Based on kinetic and DFT studies, combination of CeO2 and 2-cyanopyridine drastically enhanced the basicity of 2-cyanopyridine by a factor of about 109 (～9 by pKa (in CH3CN)), and the pKa was estimated to be ～21, which locates it in the superbase category. 2-Cyanopyridine and CeO2 formed a unique adsorption complex via two interaction modes: (i) coordinative interaction between the Ce atom of CeO2 and the N atom of the pyridine ring in 2-cyanopyridine, and (ii) covalent interaction between the surface O atom of CeO2 and the C atom of the CN group in 2-cyanopyridine by addition of the lattice oxygen of CeO2 to the CN group of 2-cyanopyridine. These interactions established a new, strongly basic site of N- over the CeO2 surface.

Method for converting amides to nitriles and nitriles to amides

A process which comprises contacting and catalytically reacting under essentially anhydrous conditions in the liquid phase an amide with a nitrile according to the equation: where R and R1 are not the same and are each selected from (1) H, hydrocarbyl, a hydrocarbyl group substituted with: one or more of F, Cl, Br, I, amido, cyano, formyl, hydrocarbylcarbonyl, hydrocarbyloxy, hydrocarbyloxycarbonyl, hydrocarbylcarbonyloxy and dihydrocarbylamino, and (2) any of group (1) where one or more H atoms are substituted by a deuterium atom,