3852-09-3

Basic information

• Product Name: Methyl 3-methoxypropionate
• Synonyms: METHYL 3-METHOXYPROPIONATE;METHYL 3-METHOXYPROPIONATE, 99+%;Methylmethoxypropanoate;Methyl β-Methoxypropionate;Methyl 3-methoxypropionate,98%;Methyl 3-methoxyprop;3-Methoxy propionate;Methyl 3-methoxypropiote
• CAS NO: 3852-09-3
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• EINECS: 223-358-1
• Product Categories: Aromatic Propionic Acids;C2 to C5;Carbonyl Compounds;Esters
• Mol File: 3852-09-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 142-143 °C(lit.)
• Flash Point: 118 °F
• Appearance: Clear colorless liquid
• Density: 1.009 g/mL at 25 °C(lit.)
• Vapor Pressure: 5.3mmHg at 25°C
• Refractive Index: n20/D 1.402(lit.)
• Storage Temp.: Flammables area
• Water Solubility: 428.60g/L(25 oC)
• BRN: 1744829
• CAS DataBase Reference: Methyl 3-methoxypropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-methoxypropionate(3852-09-3)
• EPA Substance Registry System: Methyl 3-methoxypropionate(3852-09-3)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• RTECS: UF5274000
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 3852-09-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

Methyl 3-methoxypropionate may be employed as acylation reagent for the lipase-catalyzed N-acylation of 1-phenylethanamine. It may be used in the synthesis of poly(2-hydroxylethyl 5-norbornene-2-carboxylate /t-butyl 5-norbornene-2-carboxylate /5-norbornene-2-carboxylic acid /maleic anhydride) resists. Lithographic performance of these resists was studied using ArF stepper.

General Description

Methyl 3-methoxypropionate is an ester.

InChI:InChI=1/C5H10O3/c1-7-4-3-5(6)8-2/h3-4H2,1-2H3

Synthetic route

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With sodium methylate at 60℃; for 8h;	99%
With sodium methylate; 4-methoxy-phenol at 40 - 60℃; for 6h; Temperature; Reagent/catalyst;	99%
With triethylamine at 20℃; for 8h; Temperature; Reagent/catalyst; Large scale;	98%

sodium methylate (124-41-4) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With 4-methoxy-phenol In methanol at 40 - 60℃; for 6h; Reagent/catalyst;	99%
In methanol for 24h; Heating;	54%

lithium methanolate (865-34-9) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With hydroquinone In methanol at 40℃; for 20h;	88%

methanol (67-56-1) + Tetracarbonyleisenkomplexe des Ethylens → Methyl 3-bromopropionate (3395-91-3) + methyl 3-methoxypropionate (3852-09-3) + ethylene dibromide (106-93-4) + 2-Bromoethyl methyl ether (6482-24-2)

Conditions	Yield
With bromine at -80℃; temperature up to 30 deg C;	A 67% B n/a C n/a D n/a

acrylic acid methyl ester (292638-85-8) → methyl 3-methyoxypropionate + methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With sodium methylate In methanol	A 65% B n/a

acrylic acid methyl ester (292638-85-8) + cyclohexanol (108-93-0) → methyl 3-methoxypropionate (3852-09-3) + cyclohexyl acrylate (3066-71-5) + 3-Methoxy-propionic acid cyclohexyl ester (112032-53-8)

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution;	A 22% B 23% C 52%

2-pentanol (584-02-1) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3) + 3-pentyl acrylate (4513-35-3) + 3-Methoxy-propionic acid 1-ethyl-propyl ester (112032-52-7)

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution; other temp., other time;	A 19% B 25% C 48%

acrylic acid methyl ester (292638-85-8) + isopropyl alcohol (67-63-0) → methyl 3-methoxypropionate (3852-09-3) + isopropyl acrylate (689-12-3) + isopropyl 3-methoxypropionate (10500-14-8) + 3-isopropoxy-propionic acid isopropyl ester (4220-74-0)

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution; other temp, other time;	A 17% B 15% C 42% D 26%

acrylic acid methyl ester (292638-85-8) + iso-butanol (78-92-2, 15892-23-6) → methyl 3-methoxypropionate (3852-09-3) + sec-butyl acrylate (2998-08-5) + 3-methoxy-propionic acid sec-butyl ester (112032-50-5) + 3-sec-butoxy-propionic acid sec-butyl ester (112032-51-6)

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution;	A 27% B 28% C 33% D 6%

acrylic acid methyl ester (292638-85-8) + tert-butyl alcohol (75-65-0) → tert-Butyl acrylate (1663-39-4) + methyl 3-methoxypropionate (3852-09-3) + 3-tert.-Butoxypropionsaeuremethylester (81048-08-0) + 3-Methoxy-propionic acid tert-butyl ester (112032-54-9) + tert-butyl β-tert-butoxypropionate (21150-74-3)

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution; other time, other temp.;	A 33% B 26% C 9% D 32% E 3%

(1S,2R,5S)-(+)-menthol (15356-60-2) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3) + (1S,2R,5S)‐2‐isopropyl‐5‐methylcyclohexyl acrylate (108945-28-4)

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution;	A 22% B 23%

methanol (67-56-1) + levulinic acid methyl ester (624-45-3) → methyl 3,3-dimethoxypropionate (7424-91-1) + acetic acid methyl ester (79-20-9) + methyl 3-methoxypropionate (3852-09-3) + malonic acid dimethyl ester (108-59-8) + Dimethyl succinate (106-65-0)

Conditions	Yield
With dihydrogen peroxide; toluene-4-sulfonic acid In water at 80℃; for 6h; Reagent/catalyst; Solvent; Baeyer-Villiger Ketone Oxidation; Overall yield = 22 %;	A 13% B n/a C n/a D 8% E n/a

Ketene (463-51-4) + Dimethoxymethane (109-87-5) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
at -80 - 10℃; in Gegenwart von sauren Katalysatoren;
With boron trifluoride at -80℃;

methanol (67-56-1) + β-Propiolactone (57-57-8) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With sulfuric acid at 65℃;

methyl 3-iodopropanoate (5029-66-3) + sodium methylate (124-41-4) → methyl 3-methoxypropionate (3852-09-3)

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) → 3-Methoxypropionic acid (2544-06-1) + methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With sodium

sodium methylate (124-41-4) + methyl 3-chloropropionate (6001-87-2) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
beim nachfolgendes Kochen;

methanol (67-56-1) + 3-(N-Nitroso-methoxycarbonylamino)-propionsaeure-methylester (89601-13-8) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With potassium carbonate

methanol (67-56-1) + methyl 3-bromopropanimidate hydrochloride → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
In diethyl ether

allyl acrylate (999-55-3) + sodium methylate (124-41-4) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
In methanol

methyl vinyl ketone (78-94-4) + acrylic acid methyl ester (292638-85-8) → 1-methoxybutan-3-one (6975-85-5) + methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In dichloromethane	A 28 % Chromat. B 10 % Chromat.

thiophenol (108-98-5) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3) + methyl 3-phenylthiopropanoate (22198-59-0)

Conditions	Yield
With sodium 1.) methanol; 2.) reflux, 1 h; Yield given. Multistep reaction. Yields of byproduct given;

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) → methyl 3-methoxypropionate (3852-09-3) + methyl 3-phenylthiopropanoate (22198-59-0)

Conditions	Yield
With sodium; thiophenol 1.) methanol; 2.) reflux, 1 h; Yield given. Multistep reaction. Yields of byproduct given;

methanol (67-56-1) + acrylic acid (79-10-7) → methyl 3-methoxypropionate (3852-09-3) + acrylic acid methyl ester (292638-85-8)

Conditions	Yield
With toluene-4-sulfonic acid at 111.1℃; for 0.25h; Product distribution; Kinetics; other times, temp.;

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) → methyl 3,3-dimethoxypropionate (7424-91-1) + methyl (2E)-3-methoxy-2-propenoate (5788-17-0) + methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 40℃; for 12h; Product distribution; various catalysts and temperatures;
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 40℃; for 12h;	A 91.7 % Chromat. B 1.2 % Chromat. C 2.0 % Chromat.
With supercritical CO2; oxygen; dichloro bis(acetonitrile) palladium(II); copper dichloride at 50℃; for 12h;	A 81.1 % Chromat. B 8.8 % Chromat. C 3.5 % Chromat.
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 50℃; for 12h;	A 42.9 % Chromat. B 3.1 % Chromat. C 6.6 % Chromat.

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) + sodium → methyl 3-methoxypropionate (3852-09-3)

Ketene (463-51-4) + Dimethoxymethane (109-87-5) + sulfuric acid (7664-93-9) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
at 4℃;

Ketene (463-51-4) + Dimethoxymethane (109-87-5) + boron trifluoride (7637-07-2) → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
at -80℃;

Ketene (463-51-4) + Dimethoxymethane (109-87-5) + ZnCl2 → methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
at 4℃;

methyl 3-methoxypropionate (3852-09-3) + dimethyl amine (124-40-3) → β-methoxy-N,N-dimethylpropionic acid amide (53185-52-7)

Conditions	Yield
With zinc(II) trifluoroacetate at 0 - 40℃; for 8h; Reagent/catalyst; Autoclave;	99%
With sodium methylate; glycerol at 60℃; for 6h; Autoclave;	86%
With potassium tert-butylate at 20℃; under 600.06 Torr; for 4h; Product distribution / selectivity; Autoclave;
With sodium methylate; ethylene glycol at 60℃; for 8h; Product distribution / selectivity; Autoclave;

methyl 3-methoxypropionate (3852-09-3) + (RS)-1-methyl-3-phenylpropylamine (22374-89-6) → (R)-3-methoxy-N-(4-phenylbutan-2-yl)propanamide (1322805-06-0)

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 24h; Concentration; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	98%

methyl 3-methoxypropionate (3852-09-3) + 1-aminooctadecane (124-30-1) → β-methoxy-N-stearylamide

Conditions	Yield
With iron(II) triflate In N,N-dimethyl-formamide at 80℃; for 2h;	98%

methyl 3-methoxypropionate (3852-09-3) + 2-amino-1-phenylpropane (60-15-1, 156-34-3, 51-64-9, 300-62-9) → (R)-3-methoxy-N-(1-phenylpropan-2-yl)propanamide (1322805-08-2)

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	97%

methyl 3-methoxypropionate (3852-09-3) + C12H19N → (R)-N-(4-(3,5-dimethylphenyl) butan-2-yl)-3-methoxypropanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	96%

methyl 3-methoxypropionate (3852-09-3) + C12H19N → (R)-N-(4-(2,4-dimethylphenyl)butan-2-yl)-3-methoxypropanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	95%

methyl 3-methoxypropionate (3852-09-3) + 4-methylamphetamine (64-11-9) → (R)-3-methoxy-N-(1-(p-tolyl)propan-2-yl)propanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	95%

methyl 3-methoxypropionate (3852-09-3) + C11H17N → (R)-3-methoxy-N-(4-(o-tolyl)butan-2-yl)propanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	94%

methyl 3-methoxypropionate (3852-09-3) + C11H17N → (R)-3-methoxy-N-(4-(m-tolyl)butan-2-yl)propanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	94%

methyl 3-methoxypropionate (3852-09-3) → <1,1-(2)H2>-3-methoxypropanol

Conditions	Yield
With lithium deuteride In diethyl ether for 1h; Heating;	91%
With lithium aluminium deuteride	54%
With lithium aluminium deuteride	1.82 g

methyl 3-methoxypropionate (3852-09-3) + C12H19N → (R)-N-(4-(4-ethylphenyl)butan-2-yl)-3-methoxypropanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	87%

methyl 3-methoxypropionate (3852-09-3) + 1-methyl-3-p-tolyl-propylamine (89538-71-6) → (R)-3-methoxy-N-(4-(p-tolyl)butan-2-yl)propanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	85%

methyl 3-methoxypropionate (3852-09-3) + 1-cyclohexylethylamine (4352-49-2, 5913-13-3, 17430-98-7, 54423-01-7) → (R)-N-(1-cyclohexylethyl)-3-methoxypropanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	84%

methyl 3-methoxypropionate (3852-09-3) + 2-heptylamine (123-82-0) → (R)-N-(heptan-2-yl)-3-methoxypropanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 60h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	81%

methyl 3-methoxypropionate (3852-09-3) + isopropylamine (75-31-0) → β-methoxy-N-isopropylpropionic acid amide

Conditions	Yield
With iron(II) triflate In N,N-dimethyl-formamide at 0 - 90℃; for 1h; Autoclave;	79%

1-aminodecane (2016-57-1) + methyl 3-methoxypropionate (3852-09-3) → β-methoxy-N-decylpropionamide

Conditions	Yield
With iron(II) triflate at 0 - 40℃; under 760.051 Torr; for 1h; Autoclave;	79%

rac-2-aminooctane (44855-57-4, 693-16-3) + methyl 3-methoxypropionate (3852-09-3) → (R)-3-methoxy-N-(octan-2-yl) propanamide (1322805-09-3)

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	79%
With novozyme 435 In cyclohexane at 70℃; under 7500.75 Torr; for 24h; Resolution of racemate; Inert atmosphere; Autoclave; Enzymatic reaction;

methyl 3-methoxypropionate (3852-09-3) + 4-fluoroamphetamine (459-02-9) → (R)-N-(1-(4-fluorophenyl)propan-2-yl)-3-methoxypropanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	78%

methyl 3-methoxypropionate (3852-09-3) + diethylamine (109-89-7) → 3-methoxy-N,N-diethylpropionic acid amide (5830-19-3)

Conditions	Yield
With iron(II) triflate at 0 - 100℃; for 1h; Autoclave;	76%

methyl 3-methoxypropionate (3852-09-3) + cyclohexylamine (108-91-8) → β-methoxy-N-cyclohexylpropionic acid amide

Conditions	Yield
With iron(II) triflate at 0 - 50℃; under 760.051 Torr; for 1h; Autoclave;	75%

1,5-dimethylhexylamine (543-82-8) + methyl 3-methoxypropionate (3852-09-3) → (R)-3-methoxy-N-(6-methylheptan-2-yl) propanamide (1322805-10-6)

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 48h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	74%

methyl 3-methoxypropionate (3852-09-3) + 2-amino-1-(4-methyoxyphenyl)propane (64-13-1) → (R)-3-methoxy-N-(1-(4-methoxyphenyl)propan-2-yl)propanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	72%

methyl 3-methoxypropionate (3852-09-3) + 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (135773-25-0) → 4,4'-(1-hydroxy-3-methoxypropane-1,1-diyl)bis(N,N-dimethyl-1H-imidazole-1-sulfonamide) (1258289-24-5)

Conditions	Yield
Stage #1: 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide With ethylmagnesium bromide In diethyl ether; dichloromethane at 20℃; for 2h; Double Grignard reaction; Inert atmosphere; Stage #2: methyl 3-methoxypropionate In diethyl ether; dichloromethane at 20℃; for 48h; Double Grignard reaction; Inert atmosphere; Stage #3: With water; ammonium chloride In diethyl ether; dichloromethane	71%

N-ethylhexylamine (20352-67-4) + methyl 3-methoxypropionate (3852-09-3) → β-methoxy-N-ethylhexylpropionic acid amide

Conditions	Yield
With iron(II) triflate at 0 - 25℃; under 760.051 Torr; for 1h; Autoclave;	66%

methyl 3-methoxypropionate (3852-09-3) + (+)-(R)-1-Methyl-3-(4-methoxyphenyl)-1-propylamine (51062-15-8) → (R)-3-methoxy-N-(4-(4-methoxyphenyl)butan-2-yl)propanamide

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	64%

Upstream product

• 124-41-4 sodium methylate 
• 111-70-6 n-heptan1ol 
• 292638-85-8 acrylic acid methyl ester 
• 865-34-9 lithium methanolate 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 67-56-1 methanol 
• 624-45-3 levulinic acid methyl ester 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 107-18-6 allyl alcohol 
• 106-88-7 ethyloxirane 
• 463-51-4 Ketene 
• 109-87-5 Dimethoxymethane 
• 7637-07-2 boron trifluoride 
• 7664-93-9 sulfuric acid 

Downstream Products

• 55170-74-6 5-methylhex-5-enoic acid 
• 773-14-8 2,2,3,3,4,4,5,5-Octafluoro-tetrahydro-furan 
• 354-34-7 trifluoroacetyl fluoride 
• 335-42-2 perfluorobutyryl fluoride 
• 425-38-7 perfluoro-3-methoxypropionyl fluoride 
• 5830-19-3 3-methoxy-N,N-diethylpropionic acid amide 
• 292638-85-8 acrylic acid methyl ester 
• 5621-44-3 dimethyl 2-methylenepentanedioate 
• 16096-26-7 2-methoxymethyl-glutaric acid dimethyl ester 
• 15438-67-2 (3-methoxypropyl)amide 
• 5331-41-9 allyl 3-(allyloxy)propanoate 
• 1322805-06-0 (R)-3-methoxy-N-(4-phenylbutan-2-yl)propanamide 
• 1322805-08-2 (R)-3-methoxy-N-(1-phenylpropan-2-yl)propanamide 

Relevant articles and documents

Synthesis method of methyl 3-methoxypropionate

The invention relates to a synthesis method of methyl 3-methoxypropionate, which comprises the following steps of carrying out addition reaction on absolute methanol and methyl acrylate under the condition of a catalyst which is a micromolecular tertiary amine catalyst, and after the reaction is finished, rectifying to remove excessive absolute methanol, unreacted methyl acrylate and the catalyst,collecting methyl 3-methoxypropionate with the purity of more than 99.8% as a product, and recycling the collected excessive absolute methanol, unreacted methyl acrylate and the catalyst in the nextreaction. The synthesis method has the advantages of simple synthesis, mild conditions, no need of acid neutralization, few side reactions, no three wastes, high conversion rate, long-term use of thecatalyst, repeated cyclic utilization, no damage, simplified separation process, good product quality, easy obtainment of 99.8% or above of purity, promotion of large-scale production, and facilitation of large-scale application to the photoelectric industry.

Method for preparing 3-methyl methoxypropionate

The invention relates to a method for preparing 3-methyl methoxypropionate. The method is characterized in that methyl acetate, formaldehyde and methanol are used as raw materials for reaction under the presence of a catalyst, and 3-methyl methoxypropionate is obtained. The catalyst is composed of an active component and a carrier. The active component includes a Cs metal salt, an alkali metal hydroxide and an IVB-group metal oxide. The method has the advantages in that the raw materials are low in cost, the production process is continuous and 3-methyl methoxypropionate is high in yield.

MANUFACTURING METHOD OF β-SUBSTITUTED PROPIONIC ACID AMIDE AND N-SUBSTITUTED (METH)ACRYLAMIDE

PROBLEM TO BE SOLVED: To provide a method for industrially manufacturing β-alkoxy propionic acid amide, β-amino propionic acid amide and N-substituted (meth)acryl amide using (meth)acrylic acid ester as starting material at high yield and high purity. SOLUTION: There is provided a method for obtaining N-substituted (meth)acryl amide represented by target compound formula (7) by conducting an amidation reaction with amine using β-substituted propionic acid ester represented by the formula (1) of a product of a Michael addition reaction of (meth)acrylic acid ester and alcohol or amine in presence of a metal complex as a catalyst to obtain β-substituted propionic acid amide represented by the formula (3) and conducting a thermal decomposition reaction of β-substituted propionic acid amide in presence of the metal complex as the catalyst to eliminate alcohol or amine. A-CH2-C(R1)H-C(=O)-OR2 (1), A-CH2-C(R1)H-C(=O)-N(R3)R4 (3), CH2=C(R1)-C(=O)-N(R3)R4 (7) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT