154459-82-2Relevant articles and documents
Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors
Yadav, Mahipal,Raghupathy, Riya,Saikam, Varma,Dara, Saidulu,Singh, Parvinder Pal,Sawant, Sanghapal D.,Mayor, Satyajit,Vishwakarma, Ram A.
, p. 1163 - 1172 (2014/02/14)
Synthesis of first generation non-hydrolysable C-phosphonate GPI analogs, viz., 6-O-(2-amino-2-deoxy-α-d-glucopyranosyl)-d-myo-inositol-1-O-(sn-3,4- bis(palmitoyloxy)butyl-1-phosphonate) 23a and 6-O-(2-amino-2-deoxy-α-d- glucopyranosyl)-d-myo-inositol-1-O-(sn-2,3-bis(palmitoyloxy)propyl-1- phosphonate) 23b, is reported. The target compounds were synthesized by the coupling of α-pseudodisaccharide 21 with phosphonic acids 18a and 18b respectively in quantitative yield followed by de-protection. These synthetic C-phosphonate GPI-probes were resistant to phosphatidylinositol specific phospholipase C (PI-PLC) and also showed moderate inhibition of the enzyme activity. The Royal Society of Chemistry.
Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors
Saikam, Varma,Raghupathy, Riya,Yadav, Mahipal,Gannedi, Veeranjaneyulu,Singh, Parvinder Pal,Qazi, Naveed A.,Sawant, Sanghapal D.,Vishwakarma, Ram A.
, p. 4277 - 4279 (2011/09/12)
The borondipyrromethene (BODIPY) labeled new glycosylphosphatidylinositol (GPI) molecules were synthesized as cellular probes to study the chemical basis of microdomain organization of GPI-anchored proteins and cholesterol in plasma membrane. The synthesi
Further probing of the substrate specificities and inhibition of enzymes involved at an early stage of glycosylphosphatidylinositol (GPI) biosynthesis
Crossman Jr., Arthur,Paterson, Michael J.,Ferguson, Michael A.J.,Smith, Terry K.,Brimacombe, John S.
, p. 2049 - 2059 (2007/10/03)
1-D-6-O-(2-Amino-2-deoxy-α-D-glucopyranosyl)-1-O-hexadecyl-myo-inositol (14), 1-D-6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-myo-inositol 1-(octadecyl phosphate) (18), 1-D-6-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-gly