154664-44-5Relevant academic research and scientific papers
BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS
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Page/Page column 81; 82, (2009/12/02)
There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists
Borza, Istvan,Kolok, Sandor,Galgoczy, Kornel,Gere, Aniko,Horvath, Csilla,Farkas, Sandor,Greiner, Istvan,Domany, Gyoergy
, p. 406 - 409 (2007/10/03)
A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed.
Total syntheses of the benzodiazepine alkaloids circumdatin F and circumdatin C
Witt,Bergman
, p. 2784 - 2788 (2007/10/03)
Total syntheses of circumdatin F and circumdatin C, which both possess a 3H-quinazolin-4-one as well as a 1,4-benzodiazepin-5-one moiety, are described. A tripeptide derivative was synthesized as a key intermediate and dehydrated to a benzoxazine by react
