1549812-18-1

Basic information

• Product Name: tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate
• Synonyms: tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate
• CAS NO: 1549812-18-1
• Molecular Weight: 348.445
• Mol File: 1549812-18-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate(1549812-18-1)
• EPA Substance Registry System: tert-butyl (R)-(1-(3-amino-4-(methylamino)benzoyl)piperidin-3-yl)carbamate(1549812-18-1)

Safety Data

• Hazardous Substances Data: 1549812-18-1(Hazardous Substances Data)

Upstream product

• 1549812-10-3 1,1-dimethylethyl ((3R)-1-{[4-(methylamino)-3-nitrophenyl]carbonyl}-3-piperidinyl)carbamate 
• 41263-74-5 4-(methylamino)-3-nitrobenzoic acid 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 36242-50-9 4-methylamino-3-nitro-benzoic acid methyl ester 

Relevant articles and documents

BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS

Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

2 - (AZAINDOL- 2 -YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS

Compounds of formula (I) wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O-, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C-R5 or N; B is C-R6 or N; D is C-R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.