155375-22-7

Basic information

• Product Name: 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)
• Synonyms: 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)
• CAS NO: 155375-22-7
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16
• Product Categories: PYRIDINE
• Mol File: 155375-22-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 376.6±34.0 °C(Predicted)
• Appearance: /
• Density: 1.190±0.06 g/cm3(Predicted)
• PKA: 14.49±0.50(Predicted)
• CAS DataBase Reference: 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)(155375-22-7)
• EPA Substance Registry System: 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)(155375-22-7)

Safety Data

• Hazardous Substances Data: 155375-22-7(Hazardous Substances Data)

Usage

Classification

Acrylamide derivative

Configuration

E configuration (referring to the arrangement of its double bonds)

Common Uses

Organic synthesis, chemical research, potential pharmacological agent in medicinal chemistry

Potential Applications

Drug development, building block in synthesis of various organic compounds

Safety

Requires careful handling due to potential toxicity if mishandled

Upstream product

• 99584-02-8 (E)-3-(pyridin-2-yl)acrylamide 
• 1945-84-2 2-ethynylpyridine 
• 72764-93-3 methyl 3-(pyridin-2-yl)propiolate 
• 109-04-6 2-bromo-pyridine 
• 79-06-1 2-propenamide 
• 110-86-1 pyridine 
• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 
• 7340-23-0 (E)-ethyl 3-(2-pyridyl)-propenoate 

Downstream Products

• 155375-22-7 (Z)-3-(2-Pyridyl)propenamide 
• 39077-58-2 3-(2-pyridyl)-prop-2-enyl nitrile 

Relevant articles and documents

Palladium-catalyzed C-2 selective C-H olefination of pyridines

A novel and efficient protocol for the C-2 selective olefination of pyridines via a palladium-catalyzed oxidative cross-coupling reaction has been developed. A wide range of pyridines and olefin substrates including acrylic ester, styrene, and acrylamide are compatible. The products are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules. Copyright

(E)-3-heteroaromatic propyl-2-enoic acid derivative as well as preparation and application thereof

The invention relates to a (E)-3-heteroaromatic propyl-2-enoic acid derivative, and also relates to a preparation method and pharmaceutical application thereof. The compound is a novel Nrf2 activatorand has the effects of resisting oxidative stress, resisting neuritis and enhancing mitochondrial functions and biogenesis by effectively activating an Nrf2 signal path, so that nerve cells are protected, and the compound can be used for treating neurodegenerative diseases and cerebral apoplexy. In addition, the novel Nrf2 activator can also be used to treat autoimmune diseases, diabetes and nephropathy, and other chronic diseases.

Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof

The present invention is directed to compounds effective for increasing the water solubility of poorly soluble drugs. Hydrotropic agents are identified, such as for increasing the solubility of paclitaxel. Polymerizable monomers of the hydrotropic agents