1560840-75-6

Upstream product

• 1352755-63-5 2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 7279-45-0 dichloroacetyl-carbamic acid ethyl ester 
• 455-88-9 5-nitro-2-fluorotoluene 
• 7149-75-9 3-methyl-4-chloroaniline 
• 103-90-2 4-acetaminophenol 
• 57715-76-1 2-(4-chloro-3-methyl-phenyl)-2H-[1,2,4]triazine-3,5-dione 
• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 
• 175971-60-5 2-(3-Methyl-4-hydroxyphenyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 100-00-5 4-chlorobenzonitrile 
• 955010-26-1 2-(4-(4-aminophenoxy)-3-methylphenyl)-1,2,4-triazine-3,5-(2H,4H)-dione 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Preparation method of Ethanamizuril bulk drug

The invention provides a preparation method of a Ethanamizuril bulk drug, which comprises the following steps: reacting acetaminophen and 2-fluoro-5-nitrotoluene as initial raw materials to obtain a compound II, and carrying out diazotization coupling reaction to obtain a compound IV, wherein the conjugate adopted in the diazotization coupling reaction is a compound III. According to the preparation method of the Ethanamizuril bulk drug, malonic acid monoester monoamide formate is used as a conjugate, acetaminophen and 2-fluoro-5-nitrotoluene are used as initial raw materials, construction ofa triazine ring can be realized more efficiently and mildly, and the obtained target product samipril is higher in yield and purity.

Preparation method of triazinone ring

A preparation method of a triazinone ring relates to the technical field of veterinary drugs, and comprises the following steps: carrying out a diazo condensation reaction on a condensation compound aniline and potassium ethyl malonate, carrying out an amidation reaction with sodium cyanate under an acidic condition, adding acetic acid and sodium acetate, heating, heating, and carrying out a cyclization reaction to obtain a triazinone compound. According to the method, operations such as filtration and separation are not needed before the finished product is obtained, the product loss is reduced, the method has the advantages of simple process and high yield, the yield of the salmizuril can reach 89.65%-94.81%, and the yield of the diclazuril can reach 80.20%-94.11%; and the problem of odor generation of decarboxylation reaction in the production process is also solved, and the method is beneficial to environmental protection and suitable for industrial production.

Method for preparing 2-[phenyl]-1, 2, 4-triazine-3, 5 (2H, 4H)-dione compound

The invention relates to the technical field of veterinary drugs, in particular to a method for preparing a 2-[phenyl]-1, 2, 4-triazine-3, 5 (2H, 4H)-dione compound. The method comprises the following steps: (1) taking dichloroacetyl chloride and ethyl carbamate as reaction raw materials, adding an acid-binding agent and a reaction solvent, heating, and carrying out heat preservation reaction, distillation and rectification treatment to obtain (2, 2-dichloroacetyl) ethyl carbamate; (2) adding the aniline compound as shown in the structural formula II into hydrochloric acid, treating with a diazotization reagent, a reduction reagent and an acidification reagent, and neutralizing and washing with water to obtain the phenylhydrazine compound as shown in the structural formula III; and (3) adding a phenylhydrazine compound and (2, 2-dichloroacetyl) ethyl carbamate into anhydrous acetic acid, adding a reaction aid, heating until the reaction is finished, and then carrying out distillation treatment to obtain the 2-[phenyl]-1, 2, 4-triazine-3, 5 (2H, 4H)-dione compound. By utilizing the method, the whole reaction steps are shortened, the economic benefit is improved, and the emission of three wastes is reduced.

Preparation method of anticoccidial veterinary drug ethanamizuril

The invention relates to a preparation method of an anticoccidial veterinary drug ethanamizuril, and solves the technical problems that in the prior art, an ethanamizuril production method needs ten steps of reaction, the reaction steps are tedious, the raw materials are difficult to obtain and high in price, the investment is large, the yield is low, the product quality is poor, the color is poor, and the method is not suitable for industrial production. The invention provides the preparation method of the anticoccidial veterinary drug samidazuril, wherein the preparation method comprises thefollowing steps: step 1, condensation reaction: in an organic solvent I, under the condition of an alkaline acid-binding agent, taking 2-chloro-5-nitrotoluene and acetaminophen as raw materials, carrying out condensation reaction, and separating to obtain a condensation product; step 2, reduction reaction; step 3, diazo coupling reaction; step 4, cyclization reaction; step 5, hydrolysis reaction;and 6, decarboxylation reaction to obtain the product samipril (structure 6). The method is widely applied to the technical field of veterinary drug synthesis.

Green synthesis method of anticoccidial veterinary drug Ethanamizuril

The invention relates to a green synthesis method of anticoccidial veterinary drug Ethanamizuril, and solves the technical problems that in the prior art, an Ethanamizuril production method needs tensteps of reaction, the reaction steps are complex, the raw materials are difficult to obtain and high in price, the investment is large, the yield is low, the product quality is poor, the color is poor, and the method is not suitable for industrial production. According to the green synthesis method of anticoccidial veterinary drug Ethanamizuril, 4-chloro-3-methylaniline and EPC are taken as initial raw materials, diazo coupling, cyclization, hydrolysis, decarboxylation and condensation reaction are carried out to obtain the product Ethanamizuril. The method is widely applied to the technicalfield of veterinary drug synthesis.

Triazine compound for resisting coccidiosis in chickens

This invention is involved in the field of pharmaceutical technology. It is related to a triazine compound for resisting coccidiosis in chickens, its preparation method and application. This compound has the structure below. The invented drug has good efficacy, low toxicity and is suitable for treating animal coccidiosis

Identification of in vitro metabolites of a new anticoccidial drug nitromezuril using HepG2 cells, rat S9 and primary hepatocytes by liquid chromatography/tandem mass spectrometry

RATIONALE Nitromezuril is a novel triazine compound possessing remarkable anticoccidial activity that could have possible future use in the prevention of coccidiosis; however, its metabolic characteristics have still not been revealed. METHODS In the present study, the in vitro metabolism of nitromezuril in HepG2 cells, rat S9 and primary hepatocytes was investigated using high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. The structures of metabolites and their product ions were easily and reliably characterized based on the accurate MS2 spectra and known structure of nitromezuril. RESULTS As expected, three metabolites (M1-M3) were detected in a HepG2 cells system, one metabolite was respectively detected and identified as M1 in rat S9 and M2 in rat primary hepatocytes. M1 and M2 were confirmed respectively based on comparing their retention times, full scan, product ion scan with available authentic standards and M3 was tentatively identified as hydroxyl compound of M2. CONCLUSIONS Pathways of nitromezuril were reported for the first time and no obvious species difference was shown. The proposed metabolic pathways of nitromezuril can be expected to play a key role in pharmacodynamics and food safety evaluations. Copyright