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157187-14-9

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157187-14-9 Usage

General Description

1-Fluoro-4-(pyrrolidinosulfonyl)benzene, also known as FPB, is a chemical compound with the molecular formula C12H13FNO2S. It is a fluorinated aromatic compound containing a pyrrolidinosulfonyl group and a fluoro substituent. FPB is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a valuable building block for drug discovery and development, and it exhibits potential pharmacological activity. Additionally, FPB can serve as a key intermediate in the production of various functional materials and fine chemicals. Due to its versatile reactivity and structural composition, 1-Fluoro-4-(pyrrolidinosulfonyl)benzene has applications in both chemical and pharmaceutical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 157187-14-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,1,8 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 157187-14:
(8*1)+(7*5)+(6*7)+(5*1)+(4*8)+(3*7)+(2*1)+(1*4)=149
149 % 10 = 9
So 157187-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12FNO2S/c11-9-3-5-10(6-4-9)15(13,14)12-7-1-2-8-12/h3-6H,1-2,7-8H2

157187-14-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-Fluorophenylsulfonyl)pyrrolidine

1.2 Other means of identification

Product number -
Other names 1-(4-fluorophenyl)sulfonylpyrrolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157187-14-9 SDS

157187-14-9Relevant articles and documents

Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination

Bland, Douglas C.,Lee, So Jeong,Morales-Colón, Mariá T.,Sanford, Melanie S.,Scott, Peter J. H.,See, Yi Yang

supporting information, p. 4493 - 4498 (2021/06/28)

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations is the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alcohol adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alcohol substituent (R), tetramethylammonium fluoride tert-amyl alcohol (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80 °C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles is demonstrated.

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships

Leung, Leo,Niculescu-Duvaz, Dan,Smithen, Deborah,Lopes, Filipa,Callens, Cedric,McLeary, Robert,Saturno, Grazia,Davies, Lawrence,Aljarah, Mohammed,Brown, Michael,Johnson, Louise,Zambon, Alfonso,Chambers, Tim,Ménard, Delphine,Bayliss, Natasha,Knight, Ruth,Fish, Laura,Lawrence, Rae,Challinor, Mairi,Tang, Haoran,Marais, Richard,Springer, Caroline

supporting information, p. 5863 - 5884 (2019/07/04)

Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer therapy, and thus the search for therapeutic agents against LOX has been widely sought. We report herein the medicinal chemistry discovery of a series of LOX inhibitors bearing an aminomethylenethiophene (AMT) scaffold. High-throughput screening provided the initial hits. Structure-activity relationship (SAR) studies led to the discovery of AMT inhibitors with sub-micromolar half-maximal inhibitory concentrations (IC50) in a LOX enzyme activity assay. Further SAR optimization yielded the orally bioavailable LOX inhibitor CCT365623 with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy.

TBAI-catalyzed selective synthesis of sulfonamides and β-aryl sulfonyl enamines: coupling of arenesulfonyl chlorides and sodium sulfinates with tert-amines

Jiang, Hongmei,Tang, Xiaoyue,Xu, Zhihui,Wang, Huixian,Han, Kang,Yang, Xiaolan,Zhou, Yuanyuan,Feng, Yong-Lai,Yu, Xian-Yong,Gui, Qingwen

, p. 2715 - 2720 (2019/03/12)

A simple, practical and metal-free method has been developed for the synthesis of sulfonamides and β-arylsulfonyl enamines via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides and sodium sulfinates with tert-amines. The method uses commercially available inexpensive catalysts and oxidants, and has a wide substrate scope and operational simplicity.

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