1573209-07-0

Upstream product

• 1479-22-7 ethyl 2-fluoro-3-oxo-3-phenylpropionate 
• 94-41-7 benzalacetophenone 
• 122-78-1 phenylacetaldehyde 
• 3412-44-0 (1E)-1,3-diphenylpropene 
• 124413-63-4 ethyl 3-amino-3-phenyl-2-propenoate 
• 3412-44-0 1,3-diphenylpropene 
• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 
• 117402-91-2 ethyl-2-benzoyl-3,5-diphenyl-5-oxopentanoate 
• 34989-82-7 3-methylbenzo[d]isothiazole-1,1-dioxide 
• 81-07-2 saccharin 
• 2216-94-6 phenylpropynoic acid ethyl ester 

Relevant academic research and scientific papers

2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ)-Mediated Tandem Oxidative Coupling/Intramolecular Annulation/Dehydro-Aromatization for the Synthesis of Polysubstituted and Fused Pyridines

A DDQ-mediated tandem reaction of 1,3-diarylpropenes and β-enaminoesters/4-aminocoumarins is disclosed. It involves oxidative coupling, intramolecular annulation and dehydro-aromatization reaction, which provides an efficient and mild method for the synthesis of polysubstituted and fused pyridines under metal-free conditions. (Figure presented.).

Synthetic method of ethyl 2,4,6-triphenylnicotinate

The invention discloses a synthetic method of ethyl 2,4,6-triphenylnicotinate. The method comprises the following steps of: reacting beta-enamine ester as shown in a formula I and 1,3-diphenyl propylene as shown in a formula II which are used as raw mater

Method for preparing polysubstituted pyridine

The invention discloses a method for preparing polysubstituted pyridine. The method comprises the following steps: dissolving a 1,5-dicarbonyl compound into DMSO (dimethyl sulfoxide) in a stirring manner, weighing and adding an ammonium acetate solid into a solution of the DMSO at one time, and heating and stirring a mixed solution; checking whether reaction is completed or not by virtue of a thin layer chromatography plate, cooling the reacted mixed solution to room temperature, diluting the reacted mixed solution with ethyl acetate, and washing an ethyl acetate layer for 3 to 5 times with de-ionized water; evaporating an organic phase of the ethyl acetate layer to dryness under reduced pressure, and recrystallizing a concentrate with dichloromethane to prepare a 1,2,3,5-tetra-substituted pyridine product. According to the method, the DMSO is adopted as a solvent and an oxidant, and the 1,5-dicarbonyl compound is enabled to react with ammonium acetate to generate 1,2,3,5-tetra-substituted pyridine under a heating condition. A reaction system is simple, addition of an additional oxidant and the conditions of high temperature and intense heat are avoided, and the method is particularly suitable to a pyridine structure of which three positions are substituted with ester groups.

One-Pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines

A 2-fluoro-1,3-dicarbonyl-initiated one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence is introduced for regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines as well as fused pyridines. This simple and modular synthesis is performed using readily available starting materials and under transition-metal catalyst-free conditions.

Highly functionalized pyridines synthesis from N-sulfonyl ketimines and alkynes using the N-S bond as an internal oxidant

The N-S bond-based internal oxidant offers a distinct approach for the synthesis of highly functionalized pyridines. A novel Rh(III)-catalyzed one-pot process undergoes an efficient C-C/C-N bond formation along with desulfonylation under very mild conditions. The method is quite simple, general, and efficient.