53936-95-1

Usage

Uses

Used in Pharmaceutical Industry:
(2-methylquinolin-3-yl)methanol is used as a key intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory, anti-cancer, and anti-microbial activities. Its incorporation into drug molecules can lead to the development of novel therapeutic agents with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the field of organic synthesis, (2-methylquinolin-3-yl)methanol is used as a versatile building block to create a wide range of organic compounds. Its reactivity and structural features make it an attractive candidate for the development of new synthetic pathways and the production of complex organic molecules.
Used in Drug Discovery and Development:
(2-methylquinolin-3-yl)methanol is utilized as a target compound in drug discovery and development efforts. Its potential medicinal properties and diverse reactivity offer opportunities for the creation of new drugs with innovative mechanisms of action, contributing to the advancement of modern medicine.
Used in Synthetic Organic Chemistry Research:
In synthetic organic chemistry, (2-methylquinolin-3-yl)methanol serves as an interesting target for research. Its unique structure and reactivity provide a platform for exploring new synthetic methods, reaction mechanisms, and the development of novel catalysts, further expanding the horizons of chemical science.

Upstream product

• 30160-03-3 methyl 2-methylquinoline-3-carboxylate 
• 15785-08-7 2-methyl-3-carbethoxyquinoline 
• 460316-14-7 3-(acetoxymethyl)-2-methylquinoline 
• 91-63-4 2-methylquinoline 
• 79237-43-7 1,1-Diethoxy-1,2-dihydro-cyclobuta[b]quinoline 
• 6287-35-0 ethyl 3-anilinocrotonate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 118-92-3 anthranilic acid 
• 62-53-3 aniline 
• 79237-40-4 3-bromo-2,2-dichloro-1'-formyl-1',2',3',4'-tetrahydrospiro 
• 79237-42-6 1,1-dimethoxy-1,2-dihydrocyclobutaquinoline 
• 74361-15-2 2,2-dichloro-1'-formyl-1',2'-dihydrospiro 
• 219982-00-0 3-[hydroxy-(2-nitrophenyl)methyl]but-3-en-2-one 
• 529-23-7 o-aminobenzaldehyde 

Downstream Products

• 264189-55-1 3-ethoxy-1,3-dihydrofuro[4,3-b]quinoline 
• 57032-14-1 2-hydroxymethyl-quinolin-3-yl-methanol 

Relevant academic research and scientific papers

Applications of Baylis-Hillman chemistry: One-pot convenient synthesis of functionalized (1H)-quinol-2-ones and quinolines

A simple synthesis of functionalized (1H)-quinol-2-ones and quinolines from the Baylis-Hillman adducts, i.e. alkyl 3-hydroxy-2-methylene-3-arylpropanoates and β-hydroxy-α-methylene-β-arylalkanones, respectively, has been described.

Lewis Acid-Catalyzed C(sp3)–C(sp3) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives

An efficient Lewis acid-catalyzed C(sp3)–C(sp3) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro-5H-isoquinolino[2,1-g][1,6]naphthyridine derivatives. A wide range of 2-methylquinoline-3-carbaldehydes and 1,2,3,4-tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields. (Figure presented.).

Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

Acetic Acid Promoted Redox Annulations with Dual C-H Functionalization

Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-alkylquinoline-3-carbaldehydes as well as the corresponding 4-alkyl isomers and pyridine analogues. These processes involve dual C-H bond functionalization. Acetic acid

Palladium(II)-Catalyzed ortho-Arylation of Aromatic Alcohols with a Readily Attachable and Cleavable Molecular Scaffold

A palladium(II)-catalyzed C?H arylation process of alcohols has been developed. The strategy utilizes a novel quinoline-based hemiacetal scaffold that can direct the selective C?H bond functionalization. This reaction provides a useful method to construct biaryl compounds of benzyl alcohols in good to excellent yields. The new molecular scaffold can be readily attached, removed, and recovered.

Synthesis of an analogue of lavendamycin and of conformationally restricted derivatives by cyclization via a hemiaminal intermediate

Quinoline 12 was obtained by a Friedl?nder reaction from 2-aminobenzaldehyde and methyl acetoacetate. Reduction, silylation then oxidation provided compound 8a. A Pictet-Spengler reaction between the latter and tryptophan methyl ester yielded compound 14,

Facile syntheses of ABC ring skeleton of camptothecin and related alkaloids

Facile synthetic approaches toward the preparation of ABC ring of camptothecin and related alkaloids starting from cheaper and readily available chemical reagents.

Selenium dioxide: A selective oxidising agent for the functionalisation of quinolines

A simple method is described for the preparation of 1, 3-dihydrofuro[4, 3-b]quinolin-3-ol starting from aniline and methyl acetoacetate using selenium dioxide.

FORMATION OF 1,1-DIALKOXY-1,2-DIHYDROCYCLOBUTAQUINOLINE FROM A 1',2'-DIHYDROSPIRO DERIVATIVE

1,1-Dialkoxy-1,2-dihydrocyclobutaquinolines were obtained in good yields starting from 2-methylquinoline, the key intermediate being 2,2-dichloro-1'-formyl-1',2'-dihydrospiro.