15796-65-3

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 107-18-6 allyl alcohol 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 532-27-4 1-chloroacetophenone 
• 98-86-2 acetophenone 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 217473-41-1 (+/-)-(Z)-1-(1H-1-imidazolyl)-3-phenyl-3-(1-phenylethylamino)-2-propen-1-one 
• 42287-41-2 α-methyl-N-(1-phenylethylidene)benzenemethanamine 
• 217473-64-8 (Z)-3-Phenyl-3-(1-phenyl-ethylamino)-acrylic acid allyl ester 

Downstream Products

• 3240-29-7 1-Phenylpent-4-en-1-one 
• 60669-64-9 3-hydroxy-1,5-diphenylpentan-1-one 
• 923002-42-0 C₂₃H₂₄O₄ 
• 1257228-85-5 C₂₄H₂₂O₅ 
• 1332702-62-1 allyl 2-benzoylbutanoate 
• 883901-67-5 allyl 2-methyl-3-oxo-3-phenylpropanoate 
• 1130965-30-8 (1R,5S)-1-benzoyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 1440528-11-9 allyl 2-(diphenylsulfuranylidene)-3-oxo-3-phenylpropanoate 
• 1307291-48-0 C₁₇H₁₆O₅ 
• 923002-43-1 rac-3-allyl [4-(2-ethylphenyl)-2-phenyl-1-N-(3-pyridylmethyl)-2,3-dehydro-piperidin-3-yl]carboxylate 
• 94-66-6 2-allylcyclohexan-1-one 
• 936-67-4 2-(2-methyl-2-propenyl)cyclohexanone 
• 1078-36-0 4-methyl-1-phenyl-4-pentene-1-one 

Relevant academic research and scientific papers

In situ generation of nitrile oxides from copper carbene and tert -butyl nitrite: Synthesis of fully substituted isoxazoles

Herein, we present a novel [3 + 2] cycloaddition reaction of β-keto esters with nitrile oxides, which were generated in situ from copper carbene and tert-butyl nitrite. This three-component reaction provides new methodology for the direct synthesis of fully substituted isoxazole derivatives, featuring mild reaction conditions, readily accessible starting materials and simple operation. The experimental studies and DFT calculations suggest that the reaction starts with the generation of the key intermediate nitrile oxides, followed by a [3 + 2] cycloaddition reaction of β-keto esters to give the final isoxazole products.

Pd-catalyzed domino carbonylative-decarboxylative allylation: An easy and selective monoallylation of ketones

In the presence of an allyl alcohol, α-chloroacetophenones undergo an allyloxycarbonylation reaction followed by in situ decarboxylative allylation to selectively afford the corresponding monoallylated ketones via a Pd-catalyzed domino sequence. The scope of the reaction was extended to substituted α-chloroacetophenones as well as various allyl alcohols.

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

The design and synthesis of a novel piperidine series of farnesyltransferase (FTase) inhibitors with reduced potential for metabolic glucuronidation are described. The various substitution and exchange of the phenyl group at the C-2 position of the previously described 2-(4-hydroxy)phenyl-3-nitropiperidine 1a (FTase IC50 = 5.4 nM) resulted in metabolically stable compounds with potent FTase inhibition (14a IC50 = 4.3 nM, 20a IC50 = 3.0 nM, and 50a IC50 = 16 nM). Molecular modeling studies of these compounds complexed with FTase and farnesyl pyrophosphate are also described.

A new method for the regioselective synthesis of β-enamino acid derivatives

A mild, simple and efficient route to β-enamino imidazole carbonilic derivatives 3 by reaction of ketimines with N,N′-carbonyl diimidazole in the presence of boron triflouride as catalyst has been developed. The conversion of 3 to esters has also been explored.