60669-64-9

Basic information

• Product Name: 3-Hydroxy-1,5-diphenyl-1-pentanone
• Synonyms: 3-Hydroxy-1,5-diphenyl-1-pentanone
• CAS NO: 60669-64-9
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.32362
• Mol File: 60669-64-9.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Hydroxy-1,5-diphenyl-1-pentanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-1,5-diphenyl-1-pentanone(60669-64-9)
• EPA Substance Registry System: 3-Hydroxy-1,5-diphenyl-1-pentanone(60669-64-9)

Safety Data

• Hazardous Substances Data: 60669-64-9(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-1,5-diphenyl-1-pentanone, also known as curcumin, is a naturally occurring chemical compound found in the spice turmeric. It is a member of the curcuminoid family and is known for its bright yellow color. Curcumin has been widely studied for its potential health benefits, including anti-inflammatory and antioxidant properties. It has been used in traditional medicine for centuries and has gained attention in recent years for its potential role in preventing and treating various diseases, including cancer, diabetes, and neurodegenerative disorders. Research on curcumin is ongoing, with scientists exploring its potential therapeutic applications and mechanisms of action in the human body.

Upstream product

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• 4636-16-2 iodoacetophenone 
• 64340-80-3 Dimethyl-(1-phenyl-vinyloxy)-silane 
• 98-86-2 acetophenone 
• 100-42-5 styrene 
• 253270-20-1 5-phenethyl-3-phenyl-4,5-dihydroisoxazole 

Downstream Products

• 88704-59-0 ((2S,4S,5R,6S)-4-Phenethyl-2,6-diphenyl-[1,3]dioxan-5-yl)-phenyl-methanone 
• 88764-09-4 ((2R,4R,5R,6R)-4-Phenethyl-2,6-diphenyl-[1,3]dioxan-5-yl)-phenyl-methanone 
• 134273-12-4 (2E)-5-phenyl-2-pentanophenone 
• 51238-86-9 3-methoxy-1,5-diphenyl-pentan-1-one 
• 93643-52-8 (R)-3-hydroxy-1,5-diphenyl-pentan-1-one 
• 163086-00-8 (S)-3-hydroxy-1,5-diphenyl-1-pentanone 
• 93727-51-6 threo-1,5-diphenylpentane-1,3-diol 
• 86517-85-3 1,5-diphenyl-2-pentene-1-one 

Relevant articles and documents

Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes: synthesis of β-geminal-diboryl ketones

Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis. Herein, we report an efficient strategy to synthesize β-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and allenes. This reaction promises to be a useful method for the synthesis of functionalized β-geminal-diboryl ketones with broad functional group tolerance. Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes. [Figure not available: see fulltext.]

FeCl3·6H2O-catalyzed mukaiyama-aldol type reactions of enolizable aldehydes and acetals

Mukaiyama-aldol type reactions of acetals derived from enolizable aldehydes with FeCl3·6H2O, an eco-friendly, low-cost, and stable catalyst, lead to β-methoxycarbonyl compounds with nearly quantitative yields. The methodology is extended to the parent aldehydes as starting materials, leading to the corresponding aldols with lower yields, but efficiently. Different alkyl and aryl substituted acetals and aldehydes have been tested in the reaction with linear and cyclic silyl enol ethers. Reactions are carried out in an open air atmosphere, and additives are not required. Acetals can be considered activating groups of the carbonyl moiety rather than a protecting group in this type of FeCl3·6H2O-catalyzed condensation.

Development of N,N-bis(perfluoroalkanesulfonyl)squaramides as new strong Br?nsted acids and their application to organic reactions

New strong Br?nsted acids derived from a squaric acid scaffold bearing different perfluoroalkanesulfonyl groups have been developed and applied to several organic reactions. These squaramides are bench-stable and exhibit much higher reactivities in several organic reactions than squaric acid itself. N,N-Bis(trifluoromethanesulfonyl)squaramide 2a was applied to the Mukaiyama aldol reaction and Mukaiyama Michael reaction. Mechanistic studies revealed that the Br?nsted acid might be the predominant catalyst through direct protonation of carbonyl compound by the acid itself rather than the silylated Br?nsted acid. The utility of this acid 2a was further extended to Hosomi-Sakurai allylation of aldehydes and a carbonyl-ene reaction. Furthermore, other squaramides 2b and c bearing longer perfluoroalkyl chains have been developed, which are also bench-stable and displayed similar reactivities with squaramide 2a in several organic reactions.