1580-20-7Relevant articles and documents
Selective Reduction of Saturated Perfluorocarbons
Marsella,John A.,Gilicinski, Andrew G.,Coughlin, Anne M.,Pez, Guido P.
, p. 2856 - 2860 (1992)
Perfluorocycloaliphatic compounds are reduced by solutions of the sodium benzophenone radical anion to give perfluorinated and highly fluorinated aromatic compounds.Perfluorocycloalkanes containing tertiary carbon centers are much more reactive than perfluorocyclohexane.Reduction of perfluoroalkanes and perfluorocycloalkanes that contain perfluoroalkyl substituents proceeds easily; however, it appears that overreduction occurs and no organofluorine products are obtained with these substrates.The selectivity and reactivity of several radical anion reducing agents are strongly correlated with the electrochemical behavior of the reducing agents, the perfluoroalkanes, and the observed perfluoroaromatic reduction products.Direct electrochemical reduction of saturated unsubstituted perfluoroalkanes on an analytical scale was observed for the first time in this work.
Distiboranes based onortho-phenylene backbones as bidentate Lewis acids for fluoride anion chelation
Gabba?, Fran?ois P.,Hirai, Masato,You, Di,Zhou, Benyu
, p. 4949 - 4957 (2021)
As part of our efforts in the chemistry of main group platforms that support anion sensing and transport, we are now reporting the synthesis of anitmony-based bidentate Lewis acids featuring theo-C6F4backbone. These compounds can be easily accessed by reaction of the newly synthesizedo-C6F4(SbPh2)2(5) witho-chloranil or octafluorophenanthra-9,10-quinone, affording the corresponding distiboranes6and7of general formulao-C6F4(SbPh2(diolate))2with diolate = tetrachlorocatecholate for6and octafluorophenanthrene-9,10-diolate for7, respectively. While6is very poorly soluble, its octafluorophenanthrene-9,10-diolate analog7readily dissolves in CH2Cl2and undergoes swift conversion into the corresponding fluoride chelate complex [7-μ2-F]?which has been isolated as a [nBu4N]+salt. Theo-C6H4analog of7, referred to as8, has also been prepared. Although less Lewis acidic than7,8also forms a very stable fluoride chelate complex ([8-μ2-F]?). Altogether, our experiental results, coupled with computational analyses and fluoride anion affinity calculations, show that7and8are some of the strongest antimony-based fluoride anion chelators prepared to date. Another notable aspect of this work concerns the use of the octafluorophenanthrene-9,10-diolate ligand and its ablity to impart advantageous solubility and Lewis acidity properties.
Method for assisting normal breathing in a mammal having a lung disorder
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, (2008/06/13)
A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung or hyperinflated lung syndrome, and instilling a perfluorochemical liquid into the trachea for administration in the alveolar sacs of a lung of the animal. The perfluorochemical is permeable to the ambient gas and resides substantially permanently within the alveolar sacs without inducing hyperinflated lung syndrome. The liquid is instilled in an amount sufficient to enable the animal to breathe the ambient gas normally with O2 /CO2 blood gas exchange. In another aspect of the invention, the method further includes the step of alleviating the lung disorder without inducing hyperinflated lung syndrome.
