158038-36-9

Upstream product

• 138871-58-6 (S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 138629-30-8 (S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate 
• 919349-69-2 (S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2-oxo-3-phenylselanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 910548-23-1 (3R,4R,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-3,4-pyrazolinepyrrolidin-2-one 

Downstream Products

• 158135-16-1 (4R,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one 
• 910548-24-2 (4R,5S)-N-tert-butyloxycarbonyl-5-hydroxymethyl-4-methylpyrrolidin-2-one 
• 910548-25-3 (2S,3R)-N-tert-butyloxycarbonyl-3-methylpyroglutamic acid 
• 910548-26-4 (2S,3R)-N-tert-butoxycarbonyl-3-methylglutamic acid 
• 910548-22-0 (2S,3R)-3-methylglutamic acid hydrochloride 

Relevant academic research and scientific papers

Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides

The calcium-dependent antibiotics (CDAs) and daptomycin are therapeutically relevant nonribosomal lipopeptide antibiotics that contain penultimate C-terminal 3-methyl glutamate (3-MeGlu) residues. Comparison with synthetic standards showed that (2S,3R)-co