158121-60-9

Basic information

• Product Name: Thiophene, 2-(1-phenylethyl)-
• CAS NO: 158121-60-9
• Molecular Formula: C12H12S
• Molecular Weight: 188.293
• Mol File: 158121-60-9.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Thiophene, 2-(1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2-(1-phenylethyl)-(158121-60-9)
• EPA Substance Registry System: Thiophene, 2-(1-phenylethyl)-(158121-60-9)

Safety Data

• Hazardous Substances Data: 158121-60-9(Hazardous Substances Data)

Usage

General Description

Thiophene, 2-(1-phenylethyl)- is a chemical compound that belongs to the class of organosulfur compounds. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Thiophene, 2-(1-phenylethyl)- has a thiophene ring, which is a heterocyclic aromatic ring composed of four carbon atoms and one sulfur atom. The 2-(1-phenylethyl) group attached to the thiophene ring makes the molecule more complex and adds certain properties to it. Thiophene, 2-(1-phenylethyl)- is used as a building block in the synthesis of various organic molecules and has potential applications in medicinal and agricultural chemistry.

Upstream product

• 30616-74-1 2-(1-phenylethenyl)thiophene 
• 135-00-2 2-Benzoylthiophene 
• 188290-36-0 thiophene 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 585-71-7 (1-bromoethyl)benzne 
• 100-42-5 styrene 
• 93-92-5 1-phenylethyl acetate 

Relevant articles and documents

Regiodivergent DH or HD Addition to Alkenes: Deuterohydrogenation versus Hydrodeuterogenation

The regioselective and regiodivergent addition of H-D to a variety of 1,1-diarylalkenes was realized utilizing selectively deuterated dihydroaromatic compounds, which were generated by cobalt catalysis. The reaction was initiated by catalytic amounts of B

B(C6F5)3-Catalyzed Transfer of Dihydrogen from One Unsaturated Hydrocarbon to Another

A transition-metal-free transfer hydrogenation of 1,1-disubstituted alkenes with cyclohexa-1,4-dienes as the formal source of dihydrogen is reported. The process is initiated by B(C6F5)3-mediated hydride abstraction from the dihydrogen surrogate, forming a Bronsted acidic Wheland complex and [HB(C6F5)3]-. A sequence of proton and hydride transfers onto the alkene substrate then yields the alkane. Although several carbenium ion intermediates are involved, competing reaction channels, such as dihydrogen release and cationic dimerization of reactants, are largely suppressed by the use of a cyclohexa-1,4-diene with methyl groups at the C1 and C5 as well as at the C3 position, the site of hydride abstraction. The alkene concentration is another crucial factor. The various reaction pathways were computationally analyzed, leading to a mechanistic picture that is in full agreement with the experimental observations.

Synthesis of diarylmethanes via a Friedel-Crafts benzylation using arenes and benzyl alcohols in the presence of triphenylphosphine ditriflate

Triphenylphosphine ditriflate (TPPD) was found to be an efficient promoter for the Friedel-Crafts benzylation of arenes with benzyl alcohols in CH 2Cl2 at room temperature. The good yields, the 1:1 molar ratio of arene and benzyl alcohol, the benzylation of chlorobenzene as a nonactivated aromatic compound at room temperature, and no by-product formation are the main advantages of this procedure.