158557-15-4Relevant academic research and scientific papers
Total Synthesis of the Polyene Macrolide Antibiotic Roxaticin. II. Total Synthesis of the Roxaticin
Mori, Yuji,Asai, Motoya,Kawade, Jun-ichiro,Furukawa, Hiroshi
, p. 5315 - 5330 (1995)
Roxaticin has been synthesized in a convergent manner from the polyol segment 2, which was prepared by the Julia coupling reaction of sulfone 4 and aldehyde 8, and the polyene phosphonate 3.The cyclization was achieved by macrolactonization.
Total synthesis of the polyene macrolide roxaticin
Mori, Yuji,Asai, Motoya,Kawade, Jun-Ichiro,Okumura, Akiko,Furukawa, Hiroshi
, p. 6503 - 6506 (2007/10/02)
Roxaticin has been synthesized in a convergent manner. The polyol and polyene fragments were coupled by Horner-Emmons reaction and the cyclization was achieved by macrolactonization.
