163932-35-2Relevant academic research and scientific papers
Stereochemical determination of roflamycoin: 13C acetonide analysis and synthetic correlation
Rychnovsky, Scott D.,Griesgraber, George,Schlegel, Rolf
, p. 197 - 210 (1995)
The relative configuration of natural roflamycoin (1) was determined by 13C acetonide analysis, combined with other supporting spectroscopic data. A previous proposal for the configuration of roflamycoin was shown to be incorrect. The absolute
Total Synthesis of the Polyene Macrolide Antibiotic Roxaticin. II. Total Synthesis of the Roxaticin
Mori, Yuji,Asai, Motoya,Kawade, Jun-ichiro,Furukawa, Hiroshi
, p. 5315 - 5330 (2007/10/02)
Roxaticin has been synthesized in a convergent manner from the polyol segment 2, which was prepared by the Julia coupling reaction of sulfone 4 and aldehyde 8, and the polyene phosphonate 3.The cyclization was achieved by macrolactonization.
Total synthesis of the polyene macrolide roxaticin
Mori, Yuji,Asai, Motoya,Kawade, Jun-Ichiro,Okumura, Akiko,Furukawa, Hiroshi
, p. 6503 - 6506 (2007/10/02)
Roxaticin has been synthesized in a convergent manner. The polyol and polyene fragments were coupled by Horner-Emmons reaction and the cyclization was achieved by macrolactonization.
