77877-22-6Relevant academic research and scientific papers
Total synthesis of the polyene macrolide roxaticin
Mori, Yuji,Asai, Motoya,Kawade, Jun-Ichiro,Okumura, Akiko,Furukawa, Hiroshi
, p. 6503 - 6506 (1994)
Roxaticin has been synthesized in a convergent manner. The polyol and polyene fragments were coupled by Horner-Emmons reaction and the cyclization was achieved by macrolactonization.
Total Synthesis of the Polyene Macrolide Antibiotic Roxaticin. II. Total Synthesis of the Roxaticin
Mori, Yuji,Asai, Motoya,Kawade, Jun-ichiro,Furukawa, Hiroshi
, p. 5315 - 5330 (2007/10/02)
Roxaticin has been synthesized in a convergent manner from the polyol segment 2, which was prepared by the Julia coupling reaction of sulfone 4 and aldehyde 8, and the polyene phosphonate 3.The cyclization was achieved by macrolactonization.
STEREOCHEMICAL STUDIES OF THE SKIPPED-POLYOL POLYENE MACROLIDE CLASS: DEGRADATION AND PARTIAL STURTURE DETERMINATION OF MYCOTICIN A AND B
Schreiber, Stuart L.,Goulet, Mark T.
, p. 6001 - 6004 (2007/10/02)
The degradation of prototype members of the skipped-polyol polyene macrolide class, mycoticins A and B, is reported.The characterization of the resultant fragments allows a partial stucture determination to be achieved.
THE STEREOCHEMISTRY OF AN SE2" REACTION OF A CHIRAL DIENYLMETHYLSILANE
Fleming, Ian,Kindon, Nicholas D.,Sarkar, Achintya K.
, p. 5921 - 5924 (2007/10/02)
The optically active heptadienylsilane (1) reacts with isobutyraldehyde in a stereospecifically anti reaction to give predominantly (90:10) the enantiomer (3).
