Total Synthesis of the Polyene Macrolide Antibiotic Roxaticin. II. Total Synthesis of the Roxaticin

DOI: 10.1016/0040-4020(95)00215-T

Source and publish data:

Tetrahedron p. 5315 - 5330 (1995)

Update date:2022-08-04

Topics:

Authors:

Mori, Yuji

Asai, Motoya

Kawade, Jun-ichiro

Furukawa, Hiroshi

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Article abstract of DOI:10.1016/0040-4020(95)00215-T

Roxaticin has been synthesized in a convergent manner from the polyol segment 2, which was prepared by the Julia coupling reaction of sulfone 4 and aldehyde 8, and the polyene phosphonate 3.The cyclization was achieved by macrolactonization.

Full text of DOI:10.1016/0040-4020(95)00215-T

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