1585969-17-0

Basic information

• Product Name: Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]-
• Synonyms: Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]-
• CAS NO: 1585969-17-0
• Molecular Weight: 369.055
• Mol File: 1585969-17-0.mol

Chemical Properties

• CAS DataBase Reference: Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]-(1585969-17-0)
• EPA Substance Registry System: Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]-(1585969-17-0)

Safety Data

• Hazardous Substances Data: 1585969-17-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]is utilized as an intermediate in the synthesis of new medications due to its unique structure and properties. It aids in the development of drug formulations with potential therapeutic benefits, particularly in the realm of indole-based compounds.
Used in Research Applications:
In the scientific community, this compound serves as a valuable tool for studying the effects of indole derivatives on biological systems. Its structure allows researchers to explore its interactions with various biological targets, potentially leading to a better understanding of its pharmacological profile and applications in medicine.
Used in Chemical Synthesis:
Phenol, 5-bromo-2-[(2R)-5-bromo-2,3-dihydro-1H-indol-2-yl]is employed as a key component in the synthesis of new compounds with potential applications in various fields. Its bromine substituents may contribute to the biological activity of the synthesized compounds, making it a crucial element in the creation of novel therapeutic agents.
Used in Drug Development:
This chemical compound is used as a precursor in drug development, where its unique properties can be leveraged to create new pharmaceuticals with improved efficacy and safety profiles. Its role in the development process is crucial for advancing the frontiers of medicinal chemistry.

Upstream product

• 591-20-8 3-Bromophenol 
• 1403991-85-4 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethanone 
• 1403991-82-1 3-bromophenyl 2-(2,5-dibromophenyl)acetate 
• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 
• 203314-28-7 2-(2,5-dibromophenyl)-acetic acid 
• 1585969-24-9 (R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol 
• 1585969-22-7 5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol 

Downstream Products

• 1392102-38-3 (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole 
• 1585969-26-1 (2S,2'S)-di-tert-butyl 2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate) 4-nitrobenzoic acid 
• 1585969-27-2 6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 
• 1370468-36-2 N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester 
• 1585969-16-9 (6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole 
• 1392102-37-2 (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole 

Relevant articles and documents

PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS

The present invention is directed to a process for preparing Substituted Indole Compounds of Formula (I): wherein R1, R2, R3 and R4 are as defined herein. These indole compounds are useful as synthetic intermediates for making inhibitors of HCV NS5A.

Hepatitis C virus inhibitor and application thereof

The invention relates to a hepatitis C virus inhibitor and application thereof, and particularly discloses a compound which can be used as a hepatitis C virus and is as shown in a formula (I), or optical isomer, pharmaceutically acceptable salt, hydrate or solvate thereof, which can be used for treating hepatitis C virus (HCV) infection or hepatitis C diseases, or used as a hepatitis C virus nonstructural 5A (NS5A) protein inhibitor.

PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS

The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Enantioselective synthesis of an HCV NS5a antagonist

A concise, enantioselective synthesis of the HCV NS5a inhibitor MK-8742 (1) is reported. The features of the synthesis include a highly enantioselective transfer hydrogenation of an NH imine and a dynamic diastereoselective transformation. The synthesis of this complex target requires simple starting materials and nine linear steps for completion.

Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction

A general and efficient asymmetric synthesis of cyclic indoline aminals was developed with a high level of 1,3-stereoinduction through a dynamic crystallization-driven condensation. Dehydrogenation of the indoline aminals with potassium permanganate produced the corresponding cyclic indole aminals in high yields and excellent enantioselectivities. This general methodology was successfully applied to the synthesis of a wide variety of chiral cyclic indoline aminals and indole aminals with aromatic and aliphatic functional groups.