1403991-85-4

Basic information

• Product Name: 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one
• Synonyms: 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one;1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethanone;Ethanone, 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)-;El-01
• CAS NO: 1403991-85-4
• Molecular Formula: C₁₄H₉Br₃O₂
• Molecular Weight: 448.93206
• Mol File: 1403991-85-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 497.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.963±0.06 g/cm3(Predicted)
• PKA: 6.80±0.35(Predicted)
• CAS DataBase Reference: 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one(1403991-85-4)
• EPA Substance Registry System: 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one(1403991-85-4)

Safety Data

• Hazardous Substances Data: 1403991-85-4(Hazardous Substances Data)

Usage

General Description

1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one is a complex organic compound that includes a variety of functional groups, including a ketone and a hydroxyl group. The compound is characterized by the presence of a bromine atom, with one on the fourth position of one phenyl ring and two on the second and fifth position of the other phenyl ring. Additionally, there is a hydroxy group (-OH) on the second position of the first ring and a ketone functional group (=O) on the first position of the ethane chain connecting the two phenyl rings. This chemical compound’s properties, reactivity, and uses would largely depend on these substituents and the overall molecular structure. It’s further important to note the potential presence of isomers due to the various positions of the bromine atoms. Specific information about its physical properties, toxicity, or applications is not generally available, likely indicating this compound is primarily used or studied in specific chemical or industrial contexts.

Upstream product

• 203314-28-7 2-(2,5-dibromophenyl)-acetic acid 
• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 
• 32937-55-6 1-(2,5-dibromophenyl)ethanone 
• 106-37-6 1.4-dibromobenzene 
• 591-20-8 3-Bromophenol 
• 1403991-82-1 3-bromophenyl 2-(2,5-dibromophenyl)acetate 

Downstream Products

• 1585969-22-7 5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol 
• 1585969-24-9 (R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol 
• 1585969-17-0 (R)-5-bromo-2-(5-bromoindolin-2-yl)phenol 
• 1585969-16-9 (6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole 
• 1392102-38-3 (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole 
• 1585969-26-1 (2S,2'S)-di-tert-butyl 2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate) 4-nitrobenzoic acid 
• 1585969-27-2 6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 
• 1370468-36-2 N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester 

Relevant articles and documents

An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate

Abstract: Large-scale enantioselective synthesis of the chiral amine unit of HCV NS5A inhibitor Elbasvir has been accomplished in six steps, with 55% overall yield. The process includes a highly enantioselective reduction of the NH imine using R-(+)-diphe

Hepatitis C virus inhibitor and application thereof

The invention relates to a hepatitis C virus inhibitor and application thereof, and particularly discloses a compound which can be used as a hepatitis C virus and is as shown in a formula (I), or optical isomer, pharmaceutically acceptable salt, hydrate or solvate thereof, which can be used for treating hepatitis C virus (HCV) infection or hepatitis C diseases, or used as a hepatitis C virus nonstructural 5A (NS5A) protein inhibitor.

Enantioselective synthesis of an HCV NS5a antagonist

A concise, enantioselective synthesis of the HCV NS5a inhibitor MK-8742 (1) is reported. The features of the synthesis include a highly enantioselective transfer hydrogenation of an NH imine and a dynamic diastereoselective transformation. The synthesis of this complex target requires simple starting materials and nine linear steps for completion.