1585969-22-7

Basic information

• Product Name: Phenol, 5-bromo-2-[2-(2,5-dibromophenyl)-1-iminoethyl]-
• Synonyms: Phenol, 5-bromo-2-[2-(2,5-dibromophenyl)-1-iminoethyl]-;5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol
• CAS NO: 1585969-22-7
• Molecular Formula: C₁₄H₁₀Br₃NO
• Molecular Weight: 447.9473
• Mol File: 1585969-22-7.mol

Chemical Properties

• Boiling Point: 505.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.92±0.1 g/cm3(Predicted)
• PKA: 8.02±0.40(Predicted)
• CAS DataBase Reference: Phenol, 5-bromo-2-[2-(2,5-dibromophenyl)-1-iminoethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 5-bromo-2-[2-(2,5-dibromophenyl)-1-iminoethyl]-(1585969-22-7)
• EPA Substance Registry System: Phenol, 5-bromo-2-[2-(2,5-dibromophenyl)-1-iminoethyl]-(1585969-22-7)

Safety Data

• Hazardous Substances Data: 1585969-22-7(Hazardous Substances Data)

Upstream product

• 203314-28-7 2-(2,5-dibromophenyl)-acetic acid 
• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 
• 1403991-82-1 3-bromophenyl 2-(2,5-dibromophenyl)acetate 
• 1403991-85-4 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethanone 
• 591-20-8 3-Bromophenol 
• 106-37-6 1.4-dibromobenzene 
• 32937-55-6 1-(2,5-dibromophenyl)ethanone 

Downstream Products

• 1585969-24-9 (R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol 
• 1585969-17-0 (R)-5-bromo-2-(5-bromoindolin-2-yl)phenol 
• 1585969-16-9 (6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole 
• 1392102-38-3 (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole 
• 1585969-26-1 (2S,2'S)-di-tert-butyl 2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate) 4-nitrobenzoic acid 
• 1585969-27-2 6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 
• 1370468-36-2 N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester 

Relevant articles and documents

An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate

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PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS

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Hepatitis C virus inhibitor and application thereof

The invention relates to a hepatitis C virus inhibitor and application thereof, and particularly discloses a compound which can be used as a hepatitis C virus and is as shown in a formula (I), or optical isomer, pharmaceutically acceptable salt, hydrate or solvate thereof, which can be used for treating hepatitis C virus (HCV) infection or hepatitis C diseases, or used as a hepatitis C virus nonstructural 5A (NS5A) protein inhibitor.

PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS

The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Enantioselective synthesis of an HCV NS5a antagonist

A concise, enantioselective synthesis of the HCV NS5a inhibitor MK-8742 (1) is reported. The features of the synthesis include a highly enantioselective transfer hydrogenation of an NH imine and a dynamic diastereoselective transformation. The synthesis of this complex target requires simple starting materials and nine linear steps for completion.

Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction

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