1403991-82-1

Basic information

• Product Name: Benzeneacetic acid, 2,5-dibromo-, 3-bromophenyl ester
• Synonyms: Benzeneacetic acid, 2,5-dibromo-, 3-bromophenyl ester;3-bromophenyl 2-(2,5-dibromophenyl)acetate
• CAS NO: 1403991-82-1
• Molecular Formula: C₁₄H₉Br₃O₂
• Molecular Weight: 448.93206
• Mol File: 1403991-82-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 487.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.899±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzeneacetic acid, 2,5-dibromo-, 3-bromophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2,5-dibromo-, 3-bromophenyl ester(1403991-82-1)
• EPA Substance Registry System: Benzeneacetic acid, 2,5-dibromo-, 3-bromophenyl ester(1403991-82-1)

Safety Data

• Hazardous Substances Data: 1403991-82-1(Hazardous Substances Data)

Upstream product

• 32937-55-6 1-(2,5-dibromophenyl)ethanone 
• 106-37-6 1.4-dibromobenzene 
• 203314-28-7 2-(2,5-dibromophenyl)-acetic acid 
• 591-20-8 3-Bromophenol 
• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 

Downstream Products

• 1403991-85-4 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethanone 
• 1585969-22-7 5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol 
• 1585969-24-9 (R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol 
• 1585969-17-0 (R)-5-bromo-2-(5-bromoindolin-2-yl)phenol 
• 1585969-16-9 (6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole 
• 1392102-38-3 (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole 
• 1585969-26-1 (2S,2'S)-di-tert-butyl 2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate) 4-nitrobenzoic acid 
• 1585969-27-2 6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 
• 1370468-36-2 N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester 

Relevant articles and documents

An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate

Abstract: Large-scale enantioselective synthesis of the chiral amine unit of HCV NS5A inhibitor Elbasvir has been accomplished in six steps, with 55% overall yield. The process includes a highly enantioselective reduction of the NH imine using R-(+)-diphe

Hepatitis C virus inhibitor and application thereof

The invention relates to a hepatitis C virus inhibitor and application thereof, and particularly discloses a compound which can be used as a hepatitis C virus and is as shown in a formula (I), or optical isomer, pharmaceutically acceptable salt, hydrate or solvate thereof, which can be used for treating hepatitis C virus (HCV) infection or hepatitis C diseases, or used as a hepatitis C virus nonstructural 5A (NS5A) protein inhibitor.

Enantioselective synthesis of an HCV NS5a antagonist

A concise, enantioselective synthesis of the HCV NS5a inhibitor MK-8742 (1) is reported. The features of the synthesis include a highly enantioselective transfer hydrogenation of an NH imine and a dynamic diastereoselective transformation. The synthesis of this complex target requires simple starting materials and nine linear steps for completion.