158613-21-9

Basic information

• Product Name: 3-(4-acetylphenyl)propanenitrile
• Synonyms: 3-(4-acetylphenyl)propanenitrile
• CAS NO: 158613-21-9
• Molecular Weight: 173.214
• Mol File: 158613-21-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(4-acetylphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-acetylphenyl)propanenitrile(158613-21-9)
• EPA Substance Registry System: 3-(4-acetylphenyl)propanenitrile(158613-21-9)

Safety Data

• Hazardous Substances Data: 158613-21-9(Hazardous Substances Data)

Upstream product

• 3457-45-2 p-formylacetophenone 
• 105-34-0 methyl 2-cyanoacetate 
• 105-56-6 ethyl 2-cyanoacetate 
• 99-93-4 4-Hydroxyacetophenone 
• 109613-00-5 4-acetophenyl triflate 
• 107-13-1 acrylonitrile 
• 40422-73-9 1-[4-(2-bromoethyl)phenyl]ethanone 
• 151-50-8 potassium cyanide 
• 99-91-2 para-chloroacetophenone 
• 99-90-1 para-bromoacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 75-36-5 acetyl chloride 
• 645-59-0 dihydrocinnamonitrile 

Downstream Products

• 857521-40-5 3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-propionitrile 
• 857521-42-7 3-[4-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-propionitrile 

Relevant articles and documents

Syngas Instead of Hydrogen Gas as a Reducing Agent─A Strategy To Improve the Selectivity and Efficiency of Organometallic Catalysts

Catalytic reduction reactions play a major role in modern chemistry and are often based on hydrogen gas as a reducing agent. However, the high reactivity of hydrogen is often accompanied by low selectivity on the simple catalysts. Herein, we showed that the usage of syngas as a reducing agent can be a more efficient and selective strategy. Based on control experiments, a plausible mechanism was proposed to explain the superior performance of syngas. The versatility of this approach was demonstrated by successful application to three reactions using different metal catalysts: direct reductive amination, reductive esterification, and the tandem CH-reductive alkylation-hydrolysis-decarboxylation. Catalyst turnover numbers up to 30,000 were achieved. Moreover, the developed strategy showed improved selectivity and functional group compatibility as compared to the use of hydrogen gas.

A simple route to 1,4-addition reactions by Co-catalyzed reductive coupling of organic tosylates and triflates with activated alkenes

An efficient Co-catalyzed 1,4-addition reaction of alkyl/aryl triflates and tosylates with activated alkenes is described. In this reaction, an air-stable cobalt(ii) complex, a mild reducing agent Zn and a simple proton source (H2O) are used. A radical mechanism for the addition of alkyl tosylates to activated alkenes is likely involved.

PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINES AS PDE 2 INHIBITORS

The invention provides compounds of formula (I) prodrugs thereof, and the pharmaceutically acceptable salts of the compounds or prodrugs, wherein n, X, and Y are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereo