158663-62-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 5437-45-6 Benzyl bromoacetate 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 121505-93-9 tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate 
• 4530-20-5 BOC-glycine 

Downstream Products

• 90495-99-1 N-(2-tert-butoxycarbonylaminoethyl)aminoacetic acid 
• 1027577-85-0 {[2-(benzyloxycarbonyl-benzyloxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester 
• 791778-61-5 benzyl N-[2-((fluorenylmethoxycarbonyl)amino)ethyl]glycinate 
• 388606-69-7 N-acetyl-N-(acetamidoethyl)glycine benzyl ester 
• 1352089-56-5 Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn 
• 1352089-55-4 Boc-Aeg(C[z])-Aeg(H)-Aeg(G[z])-OBn 
• 1352089-54-3 Boc-Aeg(C[z])-Aeg(Alloc)-Aeg(G[z])-OBn 
• 1352089-53-2 benzyl N-(2-(N-(allyloxycarbonyl)-N-(2-(N-(2-(4-(benzyloxycarbonylamino)-2-oxopyrimidin-1-yl)acetyl)-N-(2-(tert-butoxycarbonylamino)ethyl)glycylamino)ethyl)glycylamino)ethyl)glycinate 
• 1352089-52-1 benzyl N-(2-(N-(allyloxycarbonyl)-N-(2-(N-(2-(4-(benzyloxycarbonylamino)-2-oxopyrimidin-1-yl)acetyl)-N-(2-(tert-butoxycarbonylamino)ethyl)glycylamino)ethyl)glycylamino)ethyl)-N-((9H-fluoren-9-yl)methyloxycarbonyl)glycinate 
• 1352089-50-9 benzyl N-{2-[N-(2-tert-butoxycarbonylaminoethyl)-N-(prop-2-en-1-yloxycarbonyl)]glycylaminoethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate 
• 1421940-85-3 H-Aeg(Fmoc)-OBn*TFA 
• 923976-85-6 benzyl N-[2-(tert-butoxycarbonyl)aminoethyl]-N-[[2-N-(isobutyryl)guanin-7-yl]acetyl]glycinate 
• 312613-63-1 benzyl N-[2-(tert-butoxycarbonyl)aminoethyl]-N-[[2-N-(isobutyryl)guanin-9-yl]acetyl]glycinate 

Relevant academic research and scientific papers

Attenuated Accumulation of Novel Fluorine (19F)-Labeled Bile Acid Analogues in Gallbladders of Fibroblast Growth Factor-15 (FGF15)-Deficient Mice

Our work has focused on defining the utility of fluorine (19F)-labeled bile acid analogues and magnetic resonance imaging (MRI) to identify altered bile acid transport in vivo. In the current study, we explored the ability of this approach to d

Novel versatile fullerene synthons

We report the synthesis of three novel, versatile fullerene intermediates whose main feature is the presence of an amino end group. Simple condensation reactions of these intermediates under standard conditions produce new derivatives that are useful for

Synthesis of a hybrid fullerene-trimethoxyindole-oligonucleotide conjugate

The synthesis of novel functionalized fullerene derivatives is reported: a DNA minor groove binder such as trimethoxyindole-2-carboxylate (TMI) and an oligonucleotide chain have been covalently linked to C60 with the aim of duplicating DNA interactions for increasing sequence selectivity.

Triazine-Based Janus G-C Nucleobase as a Building Block for Self-Assembly, Peptide Nucleic Acids, and Smart Polymers

This communication reports on the utility of a triazine-based self-assembling system, reminiscent of a Janus G-C nucleobase, as a building block for developing (1) supramolecular polymers, (2) peptide nucleic acids (PNAs), and (3) smart polymers. The strategically positioned self-complementary triple H-bonding arrays DDA and AAD facilitate efficient self-assembly, leading to a linear supramolecular polymer.

PNA-DNA duplexes, triplexes, and quadruplexes are stabilized with trans-cyclopentane units

Peptide nucleic acids (PNAs) are non-natural nucleic acid mimics that bind to complementary DNA and RNA with high affinity and selectivity. PNA can bind to nucleic acids in a number of different ways. Currently, the formation of PNA-oligonucleotide duplex, triplex, and quadruplex structures have been reported. PNAs have been used in numerous biomedicial applications, but there are few strategies to predictably improve the binding properties of PNAs by backbone modification. We have been studying the benefits of incorporating (S,S)-trans-cyclopentane diamine units (tcyp) into the PNA backbone. In this Communication, we report the improvement in stability associated with tcyp incorporation into PNA-DNA duplexes, triplexes, and quadruplexes. The broad utility of this modification across multiple types of PNA structures is unique and should prove useful in the development of applications that rely on PNA. Copyright

Synthesis and molecular modeling studies of fullerene-5,6,7-trimethoxyindole-oligonucleotide conjugates as possible probes for study of photochemical reactions in DNA triple helices

The synthesis of novel functionalized fullerene derivatives containing DNA minor groove binders is reported. In order to construct sequence-specific probes for DNA photomodification, the compounds were attached to a triple helix forming oligonucleotide, and the formation of triplexes was monitored. The triplex formation was demonstrated, but the presence of fullerene moieties gives rise to a high degree of instability. Molecular modeling studies on these supramolecular structures provided useful information for the current study and for future developments.

Optimization of a solid-phase synthesis of a PNA monomer.

A new scheme for the synthesis of peptide nucleic acid (PNA) is described. First, a resin-bound amino acid is alkylated under Fukuyama-Mitsunobu conditions. A nucleobase is then incorporated via an acid fluoride. Subsequently, oligomerization may be achie

N,N-diacylpiperazine tachykinin antagonists

Diacylpiperazines of general structure STR1 are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.