Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, phenylmethyl ester

Base Information

Chemical Name:Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, phenylmethyl ester
CAS No.:158663-62-8
Molecular Formula:C16H24N2O4
Molecular Weight:308.378
Hs Code.:
Mol file:158663-62-8.mol

Synonyms:benzyl N-[2-(t-butoxylcarbonyl)aminoethyl]glycinate;N-[2-(N-Boc-amino)ethyl]glycine benzyl ester;benzyl N-[2-(tert-butoxycarbonyl)aminoethyl]glycinate;N-(t-butoxycarbonyl)-N'-(benzyloxycarbonylmethyl)ethylenediamine;

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Chemical Property of Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, phenylmethyl ester

Chemical Property:

Boiling Point:443.0±35.0 °C(Predicted)
PSA：76.66000
Density:1.105±0.06 g/cm3(Predicted)
LogP:2.62590

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, phenylmethyl ester

There total 6 articles about Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 5437-45-6
Benzyl bromoacetate

: [tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid benzyl ester

: 158663-62-8
N-((tert-butoxycarbonyl)-aminoethyl)glycine benzyl ester

Guidance literature:: With potassium fluoride; In acetonitrile; at 65 ℃; for 0.25h; Title compound not separated from byproducts;
DOI:10.1021/ol016822y

Reference yield: 80.0%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 5437-45-6
Benzyl bromoacetate

: 158663-62-8
N-((tert-butoxycarbonyl)-aminoethyl)glycine benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/acs.joc.0c02530

Reference yield:

: 4530-20-5
BOC-glycine

: 158663-62-8
N-((tert-butoxycarbonyl)-aminoethyl)glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / DMAP; triethylamine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / CH₂Cl₂ / 20 h / 0 - 20 °C

2: LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

3: 319 mg / triethylamine; NaBH(OAc)3 / CH₂Cl₂ / 1.5 h

With dmap; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja064317w