1591-43-1

Usage

Uses

Used in Fragrance Industry:
1-(4-Chlorobenzyl)naphthalene is used as a fragrance ingredient for its distinct scent, contributing to the creation of various fragrances in the perfumery and cosmetic industries.
Used in Consumer Product Manufacturing:
It is also utilized in the manufacturing of consumer products such as soaps, detergents, and personal care items, enhancing their fragrance and appeal to consumers.
Used in Pharmaceutical Research:
1-(4-Chlorobenzyl)naphthalene is used as a potential cancer preventive agent in pharmaceutical research due to its ability to inhibit the growth of cancer cells. Its study is ongoing to explore its full potential in cancer treatment and prevention.
It is crucial to handle 1-(4-Chlorobenzyl)naphthalene with care, as improper use may lead to harmful effects. Its applications span across the fragrance, consumer product, and pharmaceutical industries, showcasing its versatility and potential impact on these sectors.

Upstream product

• 147022-22-8 4-chlorophenyl-1-naphthylmethanol 
• 91-20-3 naphthalene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 116265-10-2 N,N,N-trimethyl-1-(naphthalene-1-yl)methanaminium iodide 
• 13922-41-3 1-Naphthylboronic acid 
• 622-95-7 4-chlorobenzyl bromide 
• 1352918-92-3 N-((4-chlorobenzyl)oxy)-N-methylacetamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 146450-79-5 1,1-Bis(4-chlorobenzyl)-3,4-dihydro-2(1H)-naphthalenone p-Toluenesulfonylhydrazone 
• 146450-77-3 1,1-Bis(4-chlorobenzyl)-3,4-dihydro-2(1H)-naphthalenone 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 1591-44-2 (4-chlorophenyl)(naphthalen-1-yl)methanone 
• 146450-75-1 1,1-Bis-(4-chlorobenzyl)-1,4-dihydronaphthalene 

Downstream Products

• 1591-47-5 4-(1-Naphthylmethyl)-benzophenon 
• 1591-41-9 4-(1-Naphthylmethyl)-benzhydrol 

Relevant academic research and scientific papers

The nitromethane initiator of the Friedel-Crafts naphthalene reaction using microwaves

The alkylation of naphthalene using halogen derivatives may be achieved under very simple conditions by the Friedel-Crafts reaction. The products are obtained by irradiation of the paste containing the reaction mixture and a small quantity of nitromethane to initiate the reaction.

Gold(I)-catalyzed Benzylation of (Hetero)aryl Boronic Acids with (Hetero)benzyl Bromides by the Strategy of a SN2-type Reaction

Herein, the first example of gold-catalyzed benzylation of (hetero)aryl boronic acids with (hetero)benzyl bromides to give the corresponding cross-coupling products in moderate to good yields is reported. The reaction proceeds through a possible intermolecular SN2-type reaction pathway to give a wide variety of di(hetero)arylmethanes as the desired products. An intriguing reaction mechanism has been proposed on the basis of control experiments, 31P-NMR spectroscopic detection and DFT calculations.

Efficient N-heterocyclic carbene nickel pincer complexes catalyzed cross coupling of benzylic ammonium salts with boronic acids

Pyridine-bridged bis-benzimidazolylidene nickel complexes exhibited very high catalytic activity toward cross coupling of inactive (hetero)aryl benzylic ammonium salts with (hetero)aryl and alkenyl boronic acids under mild reaction conditions. Even at 2 mol% catalyst loading, a wide range of substrates for both coupling partners with different steric and electronic properties were well tolerated.

Friedel-crafts benzylation of activated and deactivated arenes

NO going back makes possible facile Friedel-Crafts benzylations with moderate reaction temperatures, simple reaction workups, and improved substrate scope for the formation of synthetically important diarylmethanes (see scheme). Upon complexation with BF3?OEt2, hydroxamates serve as reversible leaving groups that stabilize highly reactive carbocations. Even deactivated arenes and electron-deficient benzylhydroxamates react cleanly under these conditions.