15926-46-2

Upstream product

• 100-46-9 benzylamine 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 87386-07-0 N-(thiobenzoyl)glycine ethyl ester 
• 1499-53-2 ethyl hippurate 
• 103112-01-2 N-glycine ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 15926-45-1 ethyl <(ethoxyphenylmethylidene)amino>acetate 
• 98-88-4 benzoyl chloride 
• 825-60-5 benzimidic acid ethyl ester 

Downstream Products

• 42469-73-8 2-Phenyl-N,N,N',N',-tetrapropyl-4-5-oxazoldicarboxamid 
• 42469-80-7 2-phenyl-oxazole-4,5-dicarboxylic acid bis-dimethylamide 
• 42469-47-6 2-phenyl-oxazole-4,5-dicarboxylic acid bis-isopropylamide 
• 42469-81-8 2-phenyl-oxazole-4,5-dicarboxylic acid bis-diethylamide 
• 92126-37-9 2-phenyl-4,5-bis(hydroxymethyl)oxazole bis(methylcarbamate) 
• 92126-36-8 (4-Hydroxymethyl-2-phenyl-oxazol-5-yl)-methanol 
• 42469-28-3 2-phenyl-oxazole-4,5-dicarboxylic acid diamide 
• 15926-44-0 2-phenyl-oxazole-4,5-dicarboxylic acid 
• 42469-36-3 2-phenyl-oxazole-4,5-dicarboxylic acid bis-methylamide 
• 42469-39-6 2-phenyl-oxazole-4,5-dicarboxylic acid bis-ethylamide 

Relevant academic research and scientific papers

Copper-Catalyzed Oxygenation Approach to Oxazoles from Amines, Alkynes, and Molecular Oxygen

A novel and efficient oxygenation approach to trisubstituted oxazoles via a copper-catalyzed aerobic oxidative dehydrogenative annulation of amines, alkynes, and O2 has been developed. This transformation combines dioxygen activation and oxidative C-H bond functionalization and provides a practical protocol for the preparation of oxazole derivatives, which are privileged units found in various bioactive compounds or other natural products. 18O-labeling experiments were conducted to reveal that oxygenation was involved in this chemistry.

Transformation of Alkyl N-(Vinyloxy)benzimidates to Alkyloxazoles. Mechanism and Extension

Transformation of alkyl N-(vinyloxy)benzimidates to alkyloxazoles proceeds through the intermediates: a charge-separated 1,2-oxazetidine derivative and then 1-hydroxy-2-imino>maleic acid diester, while their photochemical transformation takes place via a concerted sigmatropic shift.As the extension of this reaction, the preparation of the precursor proposed for virginiamycin M2 synthesis and the reaction of N-analogs of alkyl N-(vinyloxy)benzimidates are described.

Synthesis of oxazoles and thiazoles using thioimidates

Several oxazoles and thiazoles were synthesized easily by the reaction of N-(methylthioalkylidene)glycine ethyl ester with diethyl oxalate, acid halides, and thionesters in the presence of base.

Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents

A series of bis(hydroxymethyl)-substituted heterocycles were synthesized and converted to the corresponding bis(methylcarbamate) derivatives. The heterocyclic systems studied were based on 2-phenyl-3-methylfuran, 1-phenylpyrazole, 1-phenyl-5-methylpyrazole, 1-phenyl-5-methylthiopene, 1-phenyl-1,2,3-triazole, 3-phenylisoxazole, 3-phenylisothiazole, 2-phenylthiazole, and 2-phenyloxazole. None of the bis(carbamates) prepared was active against murine P388 lymphocytic leukemia. Pyrrole bis(carbamate), which exhibited antileukemic activity, also showed reactivity toward 4-(p-nitrobenzyl)pyridine while the inactive bis(carbamates) were unreactive in the 4-(p-nitrobenzyl)pyridine assay.