159411-91-3

Upstream product

• 6893-26-1 D-Glutamic acid 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 73915-05-6 (R)-N-(4-methoxybenzyl)glutamic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 159411-90-2 (R)-5-ethoxycarbonyl-1-(4-methoxybenzyl)-2-pyrrolidinone 

Downstream Products

• 685895-93-6 (2R)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carboxaldehyde 
• 159580-67-3 (2R,3S,5R)-5-Benzyloxymethyl-2-cyano-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-66-2 (2S,3S,5R)-5-Benzyloxymethyl-2-cyano-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-68-4 (2R,3S,5R)-5-Benzyloxymethyl-2-formyl-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-69-5 (2S,3S,5R)-5-Benzyloxymethyl-2-formyl-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-63-9 (3R,5R)-5-Benzyloxymethyl-3-methoxymethoxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-64-0 (3S,5R)-5-Benzyloxymethyl-3-methoxymethoxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159411-98-0 (R)-5-Benzyloxymethyl-3-[1-dimethylamino-meth-(Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159516-83-3 (2R,5S)-2-Benzyloxymethyl-5-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159516-85-5 (2R,5R)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159516-87-7 (2R,5S)-2-Benzyloxymethyl-5-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of chiral hydrocarbazoles via the catalytic Diels-Alder reaction of siloxyvinylindole and cyclic Z-olefin

The catalytic Diels-Alder reaction of siloxyvinylindole and cyclic Z-olefin derived from pyroglutamic acid gave optically active substituted hydrocarbazoles. The exo/endo selectivity of this reaction could be controlled by using an appropriate Lewis acid. Scandium triflate gave high exo-selectivity and copper triflate gave moderate endo-selectivity. Subsequent stereoselective alkylation of the cycloadduct led to the synthesis of highly substituted hydrocarbazoles with five continuous chiral centers including a quaternary carbon.

Synthetic studies on quinocarcin and its related compounds. 3. Synthesis of 5-substituted- and 3,5-disubstituted-2-formyl-pyrrolidine derivatives, the key D-ring fragments of enantiomeric pairs of quinocarcin and 1

The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials.