159580-63-9

Upstream product

• 100-39-0 benzyl bromide 
• 159411-98-0 (R)-5-Benzyloxymethyl-3-[1-dimethylamino-meth-(Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159411-92-4 (R)-5-Benzyloxymethyl-1-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 159411-90-2 (R)-5-ethoxycarbonyl-1-(4-methoxybenzyl)-2-pyrrolidinone 
• 73915-05-6 (R)-N-(4-methoxybenzyl)glutamic acid 
• 159411-91-3 (5R)-5-(hydroxymethyl)-1-(4-methoxybenzyl)pyrrolidin-2-one 
• 159411-93-5 (R)-5-Benzyloxymethyl-pyrrolidin-2-one 
• 159580-64-0 (3S,5R)-5-Benzyloxymethyl-3-methoxymethoxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 107-30-2 chloromethyl methyl ether 
• 107640-69-7 (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6893-26-1 D-Glutamic acid 

Downstream Products

• 159580-67-3 (2R,3S,5R)-5-Benzyloxymethyl-2-cyano-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-66-2 (2S,3S,5R)-5-Benzyloxymethyl-2-cyano-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-68-4 (2R,3S,5R)-5-Benzyloxymethyl-2-formyl-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-69-5 (2S,3S,5R)-5-Benzyloxymethyl-2-formyl-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthetic studies on quinocarcin and its related compounds. 3. Synthesis of 5-substituted- and 3,5-disubstituted-2-formyl-pyrrolidine derivatives, the key D-ring fragments of enantiomeric pairs of quinocarcin and 1

The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials.