107640-69-7Relevant academic research and scientific papers
Facile stereoselective synthesis of γ-substituted γ-amino acids from the corresponding α-amino acids
Smrcina, Martin,Majer, Pavel,Majerova, Eva,Guerassina, Tatiana A.,Eissenstat, Michael A.
, p. 12867 - 12874 (2007/10/03)
A facile stereoselective method for the synthesis of γ-substituted, γ-amino acids from α-amino acids was developed. The key step of the procedure is complete reduction of the keto functionality of α-amino acyl Meldrum's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid undergoes thermal decarboxylative ring closure to a 5-substituted pyrrolidinone which yields the corresponding γ-amino acid after basic hydrolysis. The overall yield of the procedure ranges from 40 to 65%.
Synthetic studies on quinocarcin and its related compounds. 3. Synthesis of 5-substituted- and 3,5-disubstituted-2-formyl-pyrrolidine derivatives, the key D-ring fragments of enantiomeric pairs of quinocarcin and 1
Katoh, Tadashi,Nagata, Yuriko,Kobayashi, Yuko,Arai, Katsuko,Minami, Junko,Terashima, Shiro
, p. 6221 - 6238 (2007/10/02)
The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials.
