107640-69-7

Basic information

• Product Name: (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone
• Synonyms: (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone
• CAS NO: 107640-69-7
• Molecular Weight: 305.374
• Mol File: 107640-69-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone(107640-69-7)
• EPA Substance Registry System: (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone(107640-69-7)

Safety Data

• Hazardous Substances Data: 107640-69-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 159411-93-5 (R)-5-Benzyloxymethyl-pyrrolidin-2-one 
• 34619-03-9 tert-butyldicarbonate 
• 100-39-0 benzyl bromide 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 197006-08-9 (R)-5-[(2-t-butoxycarbonylamino-3-benzyloxy)-propyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 6893-26-1 D-Glutamic acid 
• 159411-92-4 (R)-5-Benzyloxymethyl-1-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 159411-90-2 (R)-5-ethoxycarbonyl-1-(4-methoxybenzyl)-2-pyrrolidinone 
• 73915-05-6 (R)-N-(4-methoxybenzyl)glutamic acid 
• 159411-91-3 (5R)-5-(hydroxymethyl)-1-(4-methoxybenzyl)pyrrolidin-2-one 

Downstream Products

• 159411-98-0 (R)-5-Benzyloxymethyl-3-[1-dimethylamino-meth-(Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 107640-77-7 (3R,3aR,4S,7S,7aS)-7a-Benzoyl-3-benzyloxymethyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one 
• 107657-91-0 (3R,3aR,4S,7S,7aS)-7a-Acetyl-3-benzyloxymethyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one 
• 107640-67-5 (3R,3aR,7S,7aS)-7a-Acetyl-3-benzyloxymethyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one 
• 107640-74-4 (R)-3-Benzoyl-5-benzyloxymethyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 107668-03-1 (R)-3-Acetyl-5-benzyloxymethyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 159580-67-3 (2R,3S,5R)-5-Benzyloxymethyl-2-cyano-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-66-2 (2S,3S,5R)-5-Benzyloxymethyl-2-cyano-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-68-4 (2R,3S,5R)-5-Benzyloxymethyl-2-formyl-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-69-5 (2S,3S,5R)-5-Benzyloxymethyl-2-formyl-3-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-63-9 (3R,5R)-5-Benzyloxymethyl-3-methoxymethoxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159580-64-0 (3S,5R)-5-Benzyloxymethyl-3-methoxymethoxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159516-83-3 (2R,5S)-2-Benzyloxymethyl-5-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159516-85-5 (2R,5R)-2-Benzyloxymethyl-5-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Facile stereoselective synthesis of γ-substituted γ-amino acids from the corresponding α-amino acids

A facile stereoselective method for the synthesis of γ-substituted, γ-amino acids from α-amino acids was developed. The key step of the procedure is complete reduction of the keto functionality of α-amino acyl Meldrum's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid undergoes thermal decarboxylative ring closure to a 5-substituted pyrrolidinone which yields the corresponding γ-amino acid after basic hydrolysis. The overall yield of the procedure ranges from 40 to 65%.

Simplified cytochalasins. 1. Synthesis of versatile perhydroisoindolone intermediates

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