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Usage

Uses

Used in Food Industry:
Benzoic acid, 4-(4-hydroxybenzoyl)-, methyl ester is used as a preservative in the food industry to extend the shelf life of products and prevent spoilage. Its antimicrobial and antifungal properties help maintain the quality and safety of food items.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzoic acid, 4-(4-hydroxybenzoyl)-, methyl ester is used as a preservative in medications and supplements. It helps maintain the stability and potency of the products, ensuring their safety and effectiveness.
Used in Personal Care Products:
Benzoic acid, 4-(4-hydroxybenzoyl)-, methyl ester is used as a preservative in personal care products such as cosmetics, lotions, and creams. It helps prevent the growth of harmful microorganisms, ensuring the safety and longevity of these products.
Used as a Flavoring Agent:
Benzoic acid, 4-(4-hydroxybenzoyl)-, methyl ester is used as a flavoring agent in various food and beverage products. Its unique taste profile adds depth and complexity to the flavor profiles of these products.
Used as a Fragrance Ingredient:
Benzoic acid, 4-(4-hydroxybenzoyl)-, methyl ester is also used as a fragrance ingredient in perfumes, colognes, and other scented products. Its floral odor adds a pleasant and refreshing scent to these products.

Upstream product

• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 100-21-0 terephthalic acid 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 3034-86-4 4-ethynylbenzoic acid methyl ester 
• 108-95-2 phenol 
• 100-66-3 methoxybenzene 
• 1679-64-7 Monomethyl terephthalate 
• 71616-84-7 4-methoxycarbonyl-4'-methoxybenzophenone 

Downstream Products

• 1026172-43-9 4-[4-(Benzo[1,3]dioxole-5-carbonyl)-benzoyl]-benzoic acid methyl ester 
• 1026914-66-8 4-[4-(3-Trifluoromethyl-benzoyl)-benzoyl]-benzoic acid methyl ester 
• 1026567-09-8 4-[4-(4-Trifluoromethyl-benzoyl)-benzoyl]-benzoic acid methyl ester 
• 1026872-95-6 4-[4-(4-Methyl-benzyl)-benzoyl]-benzoic acid methyl ester 
• 1026403-75-7 4-[4-(4-tert-Butyl-benzoyl)-benzoyl]-benzoic acid methyl ester 
• 876611-12-0 4-[4-(benzyloxy)benzoyl]benzoic acid methyl ester 
• 876611-15-3 4-[4-(benzhydryloxy)benzoyl]benzoic acid methyl ester 
• 876611-13-1 4-(4-{[2,5-bis(trifluoromethyl)benzyl]oxy}benzoyl)benzoic acid methyl ester 
• 1236196-77-2 propargyloxybenzophenone carboxylic acid 
• 1277177-77-1 C₅₀H₆₇NO₉ 
• 1277177-78-2 C₄₂H₅₉NO₈ 
• 1277177-79-3 C₅₇H₈₄N₃O₁₅P 
• 1277177-80-6 C₅₄H₈₁N₂O₁₅P 
• 1277177-39-5 C₃₅H₄₅N₂O₁₃P 

Relevant academic research and scientific papers

Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C C Triple Bond Cleavage

Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.

Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

Trehalose dimycolates (TDMs) are the most abundant glycolipids found in the cell wall of Mycobacterium tuberculosis (M. tb). TDMs play an important role in the pathogenesis of M. tb yet the only known receptor for TDM is the macrophage inducible C-type lectin (mincle). To understand more about the interaction of TDMs with immune cells, affinity based proteome profiling (AfBPP) can be used to determine receptors that bind TDMs. To this end, we present the synthesis of the first AfBPP-TDM probe and report on its ability to activate macrophages. By doing so, we establish that the AfBPP-TDM probe appears to be a suitable substrate for future proteomic profiling experiments.

Synthesis of trifunctional phosphatidylserine probes for identification of lipid-binding proteins

Phosphatidylserine (PS) lipids play a number of roles in cell biology, one of which is to mark apoptotic cells for clearance by macrophages. PS recognition triggers macrophage recognition and clearance, which occurs concomitantly with active suppression o

Novel 5α-reductase inhibitors: Synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids

Novel substituted benzoyl benzoic acids and phenylacetic acids 1-14 have been synthesized and evaluated for inhibition of rat and human steroid 5α-reductase isozymes 1 and 2, The compounds turned out to be potent and selective human type 2 enzyme inhibitors, exhibiting IC50 values in the nanomolar range. The phenylacetic acid derivatives were more potent than the analogous benzoic acids. Bromination in the 4-position of the phenoxy moiety led to the strongest inhibitor in this class (12; IC50 = 5 nM), which was equipotent to finasteride. Since oral absorption is essential for a potential drug, 12 was further examined. In the parallel artificial membrane permeation assay (PAMPA) it turned out to be a good permeator, whereas it was a medium permeator in Caco2 cells. After oral administration (40 mg/kg) to rats a high bioavailability and a biological half-life of 5.5 h were observed, making it a promising candidate for clinical evaluation.

CHEMICAL COMPOUNDS

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.