1601-19-0

Usage

Chemical Class

Indole-3-carboxylic acids

Type

Synthetic derivative of plant hormone indole-3-acetic acid (IAA)

Usage

Plant growth regulator in agriculture

Effects on plants

Promotes root development, stimulates fruit ripening

Potential role

Inducing systemic resistance against plant pathogens

Structural features

Benzoyl and methoxy substitutions on the indole ring

Benefits

Stability and bioactivity

Applications

Horticulture and crop production

Upstream product

• 19369-69-8 N₁-benzoyl-N₁-(4-methoxyphenyl)hydrazine hydrochloride 
• 123-76-2 levulinic acid 
• 7588-36-5 methyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate 
• 13815-71-9 1-ethylidene-2-(4-methoxyphenyl)hydrazine 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 98-88-4 benzoyl chloride 
• 19155-13-6 acetaldehyde N₁-benzoyl-N₁-(4-methoxyphenyl)hydrazone 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Downstream Products

• 823177-71-5 (1-benzoyl-5-hydroxy-2-methyl-1H-indol-3-yl)acetic acid 

Relevant academic research and scientific papers

Pd/C-Et3N-mediated catalytic hydrodechlorination of aromatic chlorides under mild conditions

A mild and efficient one-pot procedure for the hydrodechlorination of aromatic chlorides using a Pd/C-Et3N system was developed. A variety of aromatic chlorides could be dechlorinated at room temperature and under ambient hydrogen pressure. Et3N activates the catalysis and is likely to work as a single electron donor in this system.

Synthesis of COX-2 and FAAH inhibitors

Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

Mild and general procedure for Pd/C-catalyzed hydrodechlorination of aromatic chlorides

A mild and efficient one-pot hydrodechlorination using a Pd/C-Et3N system proceeds at room temperature, which is general for the dechlorination of a variety of aromatic chlorides.

Synthesis of indomethacin analogues for evaluation as modulators of MRP activity

Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described. Copyright

Indole derivatives useful to treat estrogen-related neoplasms and disorders

The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.

Esters and amides of substituted pyrrole acetic acids

Esters and amides of substituted pyrrole acetic acids are useful in the treatment of colonic polyps.