1601-19-0Relevant articles and documents
Pd/C-Et3N-mediated catalytic hydrodechlorination of aromatic chlorides under mild conditions
Monguchi, Yasunari,Kume, Akira,Hattori, Kazuyuki,Maegawa, Tomohiro,Sajiki, Hironao
, p. 7926 - 7933 (2007/10/03)
A mild and efficient one-pot procedure for the hydrodechlorination of aromatic chlorides using a Pd/C-Et3N system was developed. A variety of aromatic chlorides could be dechlorinated at room temperature and under ambient hydrogen pressure. Et3N activates the catalysis and is likely to work as a single electron donor in this system.
Mild and general procedure for Pd/C-catalyzed hydrodechlorination of aromatic chlorides
Sajiki, Hironao,Kume, Akira,Hattori, Kazuyuki,Hirota, Kosaku
, p. 7247 - 7250 (2007/10/03)
A mild and efficient one-pot hydrodechlorination using a Pd/C-Et3N system proceeds at room temperature, which is general for the dechlorination of a variety of aromatic chlorides.
Indole derivatives useful to treat estrogen-related neoplasms and disorders
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, (2008/06/13)
The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.