16051-25-5Relevant articles and documents
Small-scale one-pot reductive alkylation of unprotected aminocyclitols with supported reagents
Sisa, Miroslav,Trapero, Ana,Llebaria, Amadeu,Delgado, Antonio
experimental part, p. 3167 - 3170 (2009/04/07)
A protocol for the reductive alkylation of unprotected aminocyclitols with supported reagents and scavengers is described. The method is operatively simple and provides the corresponding secondary amines in high yields and purities. Georg Thieme Verlag Stuttgart.
New aminocyclitols as modulators of glucosylceramide metabolism
Egido-Gabas, Meritxell,Serrano, Pedro,Casas, Josefina,Llebaria, Amadeu,Delgado, Antonio
, p. 1195 - 1201 (2007/10/03)
A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure-activity relationships is provided. The Royal Society of Chemistry 2005.