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1609-00-3

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1609-00-3 Usage

Description

1-METHYLBIGUANIDE SULPHATE, also known as Metformin, is a medication primarily used for the treatment of type 2 diabetes. It works by decreasing glucose production in the liver, increasing insulin sensitivity, and reducing the amount of sugar absorbed by the body. Metformin is an N-Demethylated analog with stimulatory effects on the intracellular portion of the human insulin receptor (IPβIRK).

Uses

Used in Pharmaceutical Industry:
1-METHYLBIGUANIDE SULPHATE is used as an antidiabetic drug for the treatment of type 2 diabetes. It helps to control high blood sugar levels by improving the way the body responds to insulin, which is essential for the regulation of glucose in the blood.
Additionally, Metformin has been studied for its potential use in other medical applications, such as polycystic ovary syndrome (PCOS) and certain types of cancer. However, these uses are not yet fully established and may require further research and clinical trials.

Check Digit Verification of cas no

The CAS Registry Mumber 1609-00-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,0 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1609-00:
(6*1)+(5*6)+(4*0)+(3*9)+(2*0)+(1*0)=63
63 % 10 = 3
So 1609-00-3 is a valid CAS Registry Number.

1609-00-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(diaminomethylidene)-2-methylguanidine

1.2 Other means of identification

Product number -
Other names monomethylbiguanide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1609-00-3 SDS

1609-00-3Relevant articles and documents

Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of metformin in aqueous solutions

Collin, Fabrice,Khoury,Bonnefont-Rousselot,Therond,Legrand,Jore,Gardes-Albert

, p. 890 - 902 (2004)

Metformin is an antihyperglycemic drug that exhibits some antioxidant properties. HO?-induced oxidation of metformin was studied in aqueous solution, in both aerated and deaerated conditions. Gamma radiolysis of water was used to generate HO? free radicals, capable of initiating one-electron oxidation of metformin. Oxidation end-products were identified by direct infusion mass spectrometry (MS) and high-performance liquid chromatography/mass spectrometry (HPLC/MSn): for every product, structure elucidation was based on its mass (simple mass spectra confirmed by HPLC/MS). In addition, fragmentation spectra (MS2, MS3 and MS4) and the determination of deuterium-hydrogen exchange sites provided valuable information allowing the complete identification of some of the end-products. At low radiation dose, four products were identified as primary ones, since they result from the direct attack of HO? radicals on metformin. These primary oxidation end-products were identified respectively as hydroperoxide of metformin, covalent dimer of metformin, methylbiguanide and 2-amino-4-imino-5-methyl-1,3,5-triazine. At high radiation dose, seven other products were identified as secondary ones, resulting from the HO?-induced oxidation of the primary end-products. A reaction scheme was postulated for the interpretation of the results. Copyright

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