1609-00-3

Basic information

• Product Name: 1-METHYLBIGUANIDE SULPHATE
• Synonyms: 1-METHYLBIGUANIDE SULPHATE;1-Methylbiguanide;N-Methylimidodicarbonimidic diamide;N-Methyl-N'-guanylguanidine;Metformin EP Impurity E;1-(diaminomethylidene)-2-methylguanidine
• CAS NO: 1609-00-3
• Molecular Formula: C₃H₉N₅
• Molecular Weight: 213.22
• Product Categories: Amines;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1609-00-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 107-108 °C
• Boiling Point: 165.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• PKA: 12.77±0.10(Predicted)
• CAS DataBase Reference: 1-METHYLBIGUANIDE SULPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLBIGUANIDE SULPHATE(1609-00-3)
• EPA Substance Registry System: 1-METHYLBIGUANIDE SULPHATE(1609-00-3)

Safety Data

• Hazardous Substances Data: 1609-00-3(Hazardous Substances Data)

Usage

Description

1-METHYLBIGUANIDE SULPHATE, also known as Metformin, is a medication primarily used for the treatment of type 2 diabetes. It works by decreasing glucose production in the liver, increasing insulin sensitivity, and reducing the amount of sugar absorbed by the body. Metformin is an N-Demethylated analog with stimulatory effects on the intracellular portion of the human insulin receptor (IPβIRK).

Uses

Used in Pharmaceutical Industry:
1-METHYLBIGUANIDE SULPHATE is used as an antidiabetic drug for the treatment of type 2 diabetes. It helps to control high blood sugar levels by improving the way the body responds to insulin, which is essential for the regulation of glucose in the blood.
Additionally, Metformin has been studied for its potential use in other medical applications, such as polycystic ovary syndrome (PCOS) and certain types of cancer. However, these uses are not yet fully established and may require further research and clinical trials.

Upstream product

• 593-51-1 methylamine hydrochloride 
• 127099-85-8 N-Cyanoguanidine 
• 657-24-9 dimethylbiguanide 
• 7732-18-5 water 
• 7758-99-8 copper(II) sulfate 
• 74-89-5 methylamine 
• 2123-07-1 1-benzyl-1-methyl-biguanide; hydrochloride 

Downstream Products

• 113-00-8 guanidine nitrate 
• 57-13-6 urea 
• 598-50-5 N-Methylurea 
• 129218-53-7 benzil-bis(N-methyldiamidino)diimine 

Relevant articles and documents

Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of metformin in aqueous solutions

Metformin is an antihyperglycemic drug that exhibits some antioxidant properties. HO?-induced oxidation of metformin was studied in aqueous solution, in both aerated and deaerated conditions. Gamma radiolysis of water was used to generate HO? free radicals, capable of initiating one-electron oxidation of metformin. Oxidation end-products were identified by direct infusion mass spectrometry (MS) and high-performance liquid chromatography/mass spectrometry (HPLC/MSn): for every product, structure elucidation was based on its mass (simple mass spectra confirmed by HPLC/MS). In addition, fragmentation spectra (MS2, MS3 and MS4) and the determination of deuterium-hydrogen exchange sites provided valuable information allowing the complete identification of some of the end-products. At low radiation dose, four products were identified as primary ones, since they result from the direct attack of HO? radicals on metformin. These primary oxidation end-products were identified respectively as hydroperoxide of metformin, covalent dimer of metformin, methylbiguanide and 2-amino-4-imino-5-methyl-1,3,5-triazine. At high radiation dose, seven other products were identified as secondary ones, resulting from the HO?-induced oxidation of the primary end-products. A reaction scheme was postulated for the interpretation of the results. Copyright