16112-34-8

Basic information

• Product Name: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole
• Synonyms: 1H-pyrazole, 3-(4-methylphenyl)-1,5-diphenyl-; 3-(4-Methylphenyl)-1,5-diphenyl-1H-pyrazole
• CAS NO: 16112-34-8
• Molecular Formula: C₂₂H₁₈N₂
• Molecular Weight: 310.3917
• Mol File: 16112-34-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 487.3°C at 760 mmHg
• Flash Point: 248.5°C
• Density: 1.08g/cm³
• Vapor Pressure: 3.57E-09mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole(16112-34-8)
• EPA Substance Registry System: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole(16112-34-8)

Safety Data

• Hazardous Substances Data: 16112-34-8(Hazardous Substances Data)

Usage

General Description

3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole is a chemical compound that belongs to the class of pyrazole derivatives. It is composed of a pyrazole ring with a 4-methylphenyl and two phenyl groups attached at different positions. This chemical has potential applications in the field of pharmaceuticals and materials science due to its unique structure and properties. It could potentially be used in the development of new drugs or as a building block for creating novel materials with specific characteristics. Further research and studies are needed to fully understand and explore the potential uses and properties of 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole.

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Relevant articles and documents

Synthesis of pyrazoles by a one-pot tandem cyclization-dehydrogenation approach on Pd/C/K-10 catalyst

A novel one-pot synthesis of substituted pyrazoles from chalcones and hydrazines via a tandem cyclization-dehydrogenation approach is described. This process is based on the use of a bifunctional noble-metal/solid-acid catalyst, Pd/C/K-10 montmorillonite

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.

A Regioselective Approach to Trisubstituted Pyrazoles via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines

A palladium-catalyzed oxidative carbonylation of arylhydrazines and alkynes with balloon pressure CO/O2 to afford trisubstituted pyrazoles in a one-pot manner has been developed. The formation of trisubstituted pyrazoles involves a sequential C-N bond cleavage, carbonylation, Sonogashira coupling, Michael addition, and intramolecular condensation cyclization tandem process. An unprecedented oxidative Sonogashira-carbonylation reaction of arylhydrazine plays a key role for such a facile approach to pyrazoles.