1612155-93-7Relevant articles and documents
Engaging nonaromatic, heterocyclic tosylates in reductive cross-coupling with aryl and heteroaryl bromides
Molander, Gary A.,Traister, Kaitlin M.,O'Neill, Brian T.
, p. 2907 - 2911 (2015)
A method has been developed for the introduction of nonaromatic heterocyclic structures onto aryl and heteroaryl bromides using alkyl tosylates in a reductive cross-coupling manifold. This protocol offers an improvement over previous methods by utilizing alkyl tosylate coupling partners that are bench-stable, crystalline solids that can be prepared from inexpensive, commercially available alcohols.
Reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl and heteroaryl bromides
Molander, Gary A.,Traister, Kaitlin M.,ONeill, Brian T.
, p. 5771 - 5780 (2014/07/08)
Reductive cross-coupling allows the direct C-C bond formation between two organic halides without the need for preformation of an organometallic reagent. A method has been developed for the reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl or heteroaryl bromides. The developed conditions use an air-stable Ni(II) source in the presence of a diamine ligand and a metal reductant to allow late-stage incorporation of saturated heterocyclic rings onto aryl halides in a functional-group tolerant manner.