1612155-93-7

Basic information

• Product Name: tert-butyl 4-(4-acetamidophenyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(4-acetamidophenyl)piperidine-1-carboxylate
• CAS NO: 1612155-93-7
• Molecular Weight: 318.416
• Mol File: 1612155-93-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(4-acetamidophenyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(4-acetamidophenyl)piperidine-1-carboxylate(1612155-93-7)
• EPA Substance Registry System: tert-butyl 4-(4-acetamidophenyl)piperidine-1-carboxylate(1612155-93-7)

Safety Data

• Hazardous Substances Data: 1612155-93-7(Hazardous Substances Data)

Upstream product

• 103-88-8 4-bromoacetanilide 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 636-98-6 p-nitrobenzene iodide 
• 387827-33-0 tert-butyl 4-(4-nitrophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 170011-57-1 tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate 
• 75-36-5 acetyl chloride 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 

Relevant articles and documents

Engaging nonaromatic, heterocyclic tosylates in reductive cross-coupling with aryl and heteroaryl bromides

A method has been developed for the introduction of nonaromatic heterocyclic structures onto aryl and heteroaryl bromides using alkyl tosylates in a reductive cross-coupling manifold. This protocol offers an improvement over previous methods by utilizing alkyl tosylate coupling partners that are bench-stable, crystalline solids that can be prepared from inexpensive, commercially available alcohols.

Reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl and heteroaryl bromides

Reductive cross-coupling allows the direct C-C bond formation between two organic halides without the need for preformation of an organometallic reagent. A method has been developed for the reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl or heteroaryl bromides. The developed conditions use an air-stable Ni(II) source in the presence of a diamine ligand and a metal reductant to allow late-stage incorporation of saturated heterocyclic rings onto aryl halides in a functional-group tolerant manner.