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16148-06-4 Usage


1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one is an intermediate in the synthesis of Pimozide (D453300), a D2 dopamine receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 16148-06-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,4 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16148-06:
94 % 10 = 4
So 16148-06-4 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name R 4782

1.2 Other means of identification

Product number -
Other names 1-(1-benzylpiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16148-06-4 SDS

16148-06-4Downstream Products

16148-06-4Relevant articles and documents

Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J- 113397)

Kawamoto, Hiroshi,Ozaki, Satoshi,Itoh, Yoshiki,Miyaji, Mitsuru,Arai, Sachie,Nakashima, Hiroshi,Kato, Tetsuya,Ohta, Hisashi,Iwasawa, Yoshikazu

, p. 5061 - 5063 (1999)


Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives

Rondanin, Riccardo,Simoni, Daniele,Romagnoli, Romeo,Baruchello, Riccardo,Marchetti, Paolo,Costantini, Cristiana,Fochi, Sara,Padroni, Giacomo,Grimaudo, Stefania,Pipitone, Rosaria Maria,Meli, Maria,Tolomeo, Manlio

supporting information, p. 4568 - 4574 (2015/02/19)

STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

2-oxoimidazole derivatives


, (2008/06/13)

The present invention relates to a compound represented by Formula [I] wherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R1represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)-amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R2represents a hydrogen atom or a lower alkyl group, a salt or ester thereof, a production process for the same, and an analgesic, a reliever against tolerance to a narcotic analgesic represented by morphine, a reliever against dependence on a narcotic analgesic represented by morphine, an analgesic enhancer, an antiobestic, a drug for ameliorating brain function, a remedy for schizophrenia, a remedy for Parkinsonism, a remedy for chorea, an antidepressant, a remedy for diabetes insipidus, a remedy for polyuria, or a remedy for hypotension, comprising an effective ingredient of the same.

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