16156-53-9

Usage

Uses

Used in Organic Synthesis:
2-Methylpropylmethanesulphonate is used as a reagent for its mild and selective methylation properties, facilitating the synthesis of various organic compounds. Its ability to participate in organic synthesis reactions without causing harsh side effects or requiring extreme conditions makes it a preferred choice in the laboratory and industrial settings.
Used as a Solvent in Chemical Reactions:
In the realm of chemical reactions, 2-Methylpropylmethanesulphonate serves the critical role of a solvent. Its capacity to dissolve a wide range of substances and its stability under various conditions make it suitable for numerous applications, thereby enhancing the efficiency and outcomes of chemical processes.
Used as a Stabilizer in Formulations:
2-Methylpropylmethanesulphonate is utilized as a stabilizer in certain formulations to maintain the integrity and effectiveness of the end product. Its stabilizing properties help to prevent degradation or unwanted changes, ensuring the reliability and consistency of the formulation over time.
Overall, 2-Methylpropylmethanesulphonate's versatility in different applications across various industries is a testament to its utility and importance in the field of chemistry.

InChI:InChI=1/C5H12O3S/c1-5(2)4-8-9(3,6)7/h5H,4H2,1-3H3

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 7143-01-3 Methanesulfonic anhydride 

Downstream Products

• 32752-09-3 Diisobutyl-peroxid 
• 918900-74-0 benzyl 6-deoxy-6-(isobutylsulfonomethyl)-2,3,4-tri-O-benzyl-β-D-glucopyranoside 
• 918900-75-1 benzyl 6-deoxy-6-[(isobutylsulfono)fluoromethyl]-2,3,4-tri-O-benzyl-β-D-glucopyranoside 
• 918900-76-2 benzyl 6-deoxy-6-[(isobutylsulfono)difluoromethyl]-2,3,4-tri-O-benzyl-β-D-glucopyranoside 
• 66868-67-5 4-(2-methylpropyl)sulfenyl-2-nitroaniline 
• 1352399-57-5 isobytyl 4-(cyclohexa-1,4-dien-1-yl)butane-1-sulfonate 
• 74792-80-6 2-hydroxy-2-methylpropyl methanesulfonate 
• 122836-35-5 sulfentrazone 
• 359-00-2 1-fluoro-2-methylpropane 
• 2088-35-9 1,1-dichlorocyclopropane 
• 115-11-7 isobutene 
• 161798-03-4 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Electrochemical Deoxygenative Thiolation of Preactivated Alcohols and Ketones

This work describes an electrochemically promoted nickel-catalyzed deoxygenative thiolation of alcohols and ketones under mild conditions. Excellent substrate tolerance and good chemical yields can be achieved by graphene/nickel foam electrodes in an undivided cell. Further study to gain mechanistic insight into this electrochemical cross-coupling has been carried out.

New preparation method of febuxostat intermediate

The invention relates to a new preparation method of a febuxostat intermediate. The method includes: taking cheap 4-hydroxybenzaldehyde as an initial raw material, firstly preparing aldoxime from 4-hydroxybenzaldehyde and hydroxylamine hydrochloride, then adding a corresponding thio reagent, and preparing a compound 4-hydroxythiobenzamide (152A1-00) by Beckmann rearrangement reaction; utilizing one-pot process, adopting cheap 4-hydroxybenzaldehyde as an initial raw material, carrying out a series of reactions, and then performing cyclization with 2-halogenated ethyl acetoacetate to obtain ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate or different salt forms (152A2x) thereof; and using isobutyl sulfonate (152H1x) with more easily controllable quality to replace bromo-isobutane soas to prepare ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate (152A4-00). In conclusion, the method provided by the invention is more beneficial to safe, simple and cost-efficientindustrial scale preparation of the febuxostat intermediate with higher purity.

Multi-Gram Scale Synthesis of 1,2,3-Triazolium Ionic Liquids and Assay of Their Resistance towards Bases

An easily upscalable synthesis method for 1,2,3-triazolium ionic liquids is presented. Several ionic liquids were synthesized and characterized. The influence of the side chain structure on the base-stability was investigated. One example, functionalized with linear alkyl side chains, was found to exhibit excellent stability against hot concentrated NaOH solutions and Grignard reagents.

Synthesis, dynamic combinatorial chemistry, and PCR amplification of 3'-5' and 3'-6' disulfide-linked oligonucleotides

Disulfide dithymidines linked 3'-5' or 3'-6' were synthesized and incorporated into oligonucleotides through a combined phosphotriester and phosphoramidite solid-phase oligonucleotide synthesis approach. The disulfide links are cleaved and formed reversibly in the presence of thiols and oligonucleotides. This link was shown to be sequence-adaptive in response to given templates in the presence of mercaptoethanol. The artificial 3'-5' and 3'-6' disulfide link was tolerated by polymerases in the polymerase chain reaction (PCR). By using sequencing analysis, we show that single mutations frequently occurred randomly in the amplification products of the PCR.

HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS

A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy,-CN,-C(Rc)2OH,-N(Rd)C(=X)Rc,-C(=X)N(Rc)(Rd),-S(O)m-Rc,-N(Rc)(Rd)S(O)2,-S(O)2N(R c)(Rd),-N(Re)2, aryl optionally substituted with Ra or-O-aryl optionally substituted with Ra; or B is present and is-(CH2)n-,-C(Rb)2-or-O-, or B taken together with A or Z can be-C=C(Rb)-,-C(Rb)=C-,-CH2-CH(R b)-or-CH(Rb)-CH2-; D is-O-or-S(O) m,-; E is a bond or is-(CH2)n-,-N(R d)-,-(CH2)nN(Rd)-or-N(R d)(CH2)n-; F is-C(=X)-; G is-(CH2 )n-,-N(Rd)-,-(CH2)nN(R d)-or-N(Rd)(CH2)n; J is a bond,-O-,-N(RC)C(=X)-,-C(=X)N(Rc)-,-S(O)m,-,-N(Rc)S(O)m-,-S(O)nN(Rc)-,-N(Re)-or-N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.

Method of treating helminthiasis by parenteral or topical administration of sulfoxide derivatives of benzimidazoles

A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfoxide derivatives of benzimidazoles having the structure STR1 wherein R1 is lower alkyl or phenyl-lower alkyl, and R2 is lower alkyl. Pharmaceutical compositions for use in the above method are also provided.