1620758-33-9

Basic information

• Synonyms: Jardiance Impurity A;(2R,3R,4R,5S,6R)-2-(3-((S)-4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
• CAS NO: 1620758-33-9
• Molecular Formula: C23H27ClO7
• Molecular Weight: 450.90928
• Mol File: 1620758-33-9.mol
• Article Data: 52

Chemical Properties

• Boiling Point: 664.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.398±0.06 g/cm3(Predicted)
• PKA: 13.23±0.70(Predicted)
• CAS DataBase Reference: N/A(CAS DataBase Reference)
• NIST Chemistry Reference: N/A(1620758-33-9)
• EPA Substance Registry System: N/A(1620758-33-9)

Safety Data

• Hazardous Substances Data: 1620758-33-9(Hazardous Substances Data)

Usage

Uses

Empagliflozin α-Anomer is a derivative of Empagliflozin (E521510), a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control syndrome in diabetic rats.

Upstream product

• 864070-37-1 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 112052-11-6 toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester 
• 219823-47-9 (R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate 
• 1198-69-2 D-glucono-1,4-lactone 
• 90-80-2 D-Glucono-1,5-lactone 
• 915095-94-2 (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran 
• 32469-28-6 (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 
• 915095-87-3 (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone 
• 1279691-36-9 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 19094-56-5 2-chloro-5-iodobenzoic acid 
• 108-24-7 acetic anhydride 
• 281652-58-2 2-chloro-5-iodobenzoylchloride 
• 915095-86-2 (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone 
• 915095-96-4 methyl-1-C-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucopyranoside 

Relevant articles and documents

SELECTIVE VALORIZATION OF BIOMASS SUGARS

Disclosed are methods of forming an epimer or a dehydrated isomer of a pyranose monosaccharide or a pyranose saccharide residue in an oligosaccharide or a glycoside.

Synthetic method of empagliflozin

The invention discloses a synthesis method of empagliflozin. According to the method, (S)-3-(4-(5-bromo-2-chlorobenzyl) phenoxy) tetrahydrofuran is adopted as a starting raw material and is coupled with 2, 3, 4, 6-tetrabenzyl-D-glucopyranosyl-1, 5-lactone under the catalysis of Pd2 (dba) 3 and the combined action of p-toluenesulfonhydrazide, Xphos and lithium tert-butoxide to generate an intermediate I, double bonds of the intermediate I are subjected to hydrogenation reduction through raney nickel, meanwhile, debenzylation is conducted, and the empagliflozin is obtained. The method does not need butyl lithium, Grignard reagent and other dangerous materials, has the advantages of short reaction route, simple reaction and post-treatment, high safety, few side reactions, high product yield and high purity, and is especially suitable for industrial production.

Preparation method of SGLT-2 inhibitor and intermediate

The invention discloses a preparation method of an SGLT-2 inhibitor and an intermediate. The method comprises the following steps: (1) reacting a compound A with chlorosilane under the action of an acid-binding agent to generate a compound B; (2) mixing the compound B and a compound C to obtain a compound D; and (3) reacting the compound D with a reducing agent and a catalyst to obtain the SGLT-2 inhibitor compound.