16208-93-8

Upstream product

• 589-21-9 (4-bromophenyl)hydrazine 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 10449-07-7 (2-chlorophenyl)hydrazine 
• 100-63-0 phenylhydrazine 
• 1428183-79-2 3,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole 
• 62546-27-4 1-(4-bromophenyl)-3, 5-dimethyl-1H-pyrazole 
• 51560-55-5 1-(4-chlorophenyl)-3, 5-dimethyl-1H-pyrazole 
• 1131-16-4 3,5-dimethyl-1-phenyl-1H-pyrazole 
• 95430-69-6 1,1-bis(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methane 
• 365-34-4 2-(trifluoromethyl)phenylhydrazine 

Relevant academic research and scientific papers

Oxone-DMSO Triggered Methylene Insertion and C(sp2)-C(sp3)-H-C(sp2) Bond Formation to Access Functional Bis-Heterocycles

Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)-C(sp3)-H-C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bis-pyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.