95430-69-6

Upstream product

• 58789-53-0 1-Phenyl-4-hydroxymethyl-3,5-dimethyl-pyrazol 
• 50-00-0 formaldehyd 
• 1152595-49-7 3,5-dimethyl-1-phenyl-4-(chloromethyl)-1H-pyrazole 
• 1131-16-4 3,5-dimethyl-1-phenyl-1H-pyrazole 
• 589-21-9 (4-bromophenyl)hydrazine 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 10449-07-7 (2-chlorophenyl)hydrazine 
• 100-63-0 phenylhydrazine 
• 1428183-79-2 3,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole 
• 218632-21-4 1-(4-methoxyphenyl)-3,5-dimethyl-1H-pyrazole 
• 62546-27-4 1-(4-bromophenyl)-3, 5-dimethyl-1H-pyrazole 
• 51560-55-5 1-(4-chlorophenyl)-3, 5-dimethyl-1H-pyrazole 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 70-29-1 diethyl sulphide 

Downstream Products

• 16208-93-8 bis(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanone 

Relevant academic research and scientific papers

Oxone-DMSO Triggered Methylene Insertion and C(sp2)-C(sp3)-H-C(sp2) Bond Formation to Access Functional Bis-Heterocycles

Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)-C(sp3)-H-C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bis-pyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.

Reactions of 3,5-dimethyl-1-phenyl-1h-pyrazole with electrophiles

Reactions of 3,5-dimethyl-1-phenyl-1H-pyrazole with various electrophilic reagents were studied. Electrophilic attack occurred regioselectively at the C4 atom in the pyrazole ring. Pleiades Publishing, Ltd., 2012.