16212-07-0

Basic information

• Product Name: DIOXO(PHENYL)(3-PHENYL-2-PROPENYL)-LAMBDA6-SULFANE
• Synonyms: DIOXO(PHENYL)(3-PHENYL-2-PROPENYL)-LAMBDA6-SULFANE;PHENYLCINNAMYLSULFONE;PHENYL 3-PHENYL-2-PROPENYL SULFONE;(E)-1-Phenyl-3-(phenylsulfonyl)-1-propene;[(E)-3-Phenyl-2-propenyl]phenyl sulfone;[(E)-3-Phenylallyl]phenyl sulfone;Phenyl(E)-cinnamyl sulfone;trans-Cinnamylphenyl sulfone
• CAS NO: 16212-07-0
• Molecular Formula: C₁₅H₁₄O₂S
• Molecular Weight: 258.34
• Mol File: 16212-07-0.mol
• Article Data: 30

Chemical Properties

• Melting Point: 110-111 °C
• Boiling Point: 460.3±38.0 °C(Predicted)
• Appearance: /
• Density: 1.192±0.06 g/cm3(Predicted)
• CAS DataBase Reference: DIOXO(PHENYL)(3-PHENYL-2-PROPENYL)-LAMBDA6-SULFANE(CAS DataBase Reference)
• NIST Chemistry Reference: DIOXO(PHENYL)(3-PHENYL-2-PROPENYL)-LAMBDA6-SULFANE(16212-07-0)
• EPA Substance Registry System: DIOXO(PHENYL)(3-PHENYL-2-PROPENYL)-LAMBDA6-SULFANE(16212-07-0)

Safety Data

• Hazardous Substances Data: 16212-07-0(Hazardous Substances Data)

Upstream product

• 21040-45-9 Cinnamyl acetate 
• 873-55-2 sodium benzenesulfonate 
• 4392-24-9 Cinnamyl bromide 
• 98-09-9 benzenesulfonyl chloride 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 13603-85-5 (3-phenylprop-2-yne-1-sulfonyl)benzene 
• 108-98-5 thiophenol 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 24224-99-5 benzenesulfonyl cyanide 
• 5848-60-2 (E)-1-phenyl-3-(phenylthio)propene 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 56069-39-7 diethyl phenylsulfonylmethylphosphonate 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 81635-10-1 C₁₆H₁₄F₂O₂S 
• 1076-66-0 3-phenyl-1,5-hexadiene 
• 56644-04-3 (E)-1-phenyl-1,5-hexadiene 
• 300-57-2 allylbenzene 
• 873-66-5 1-propenylbenzene 
• 117749-19-6 (E)-1,4-diphenyl-3-(phenylsulphonyl)-1-butene 
• 134436-10-5 ((E)-1-Benzenesulfonyl-3-phenyl-allyl)-trimethyl-silane 
• 64495-62-1 4-benzenesulfonyl-2-phenyl-quinoline 
• 204913-33-7 4-Benzenesulfonyl-6-chloro-2-phenyl-quinoline 

Relevant articles and documents

Palladium-triethylborane-triggered direct and regioselective conversion of allylic alcohols to allyl phenyl sulfones?

A combination of Pd(OAc)2 (5 mol %), PPh3 (10 mol %), and Et3B (200 mol %) promotes the formation of allyl phenyl sulfones from the allylic alcohols directly with excellent yields under mild conditions. The activation of an alcohol group is not necessary which is achieved in situ. The conjugated dienols also were equally effective for the said transformation.

Reciprocal-Activation Strategy for Allylic Sulfination with Unactivated Allylic Alcohols

A reciprocal-activation strategy for allylic sulfination with unactivated allylic alcohols was developed. In this reaction, the hydrogen bond interaction between allylic alcohols and sulfinic acids allowed for reciprocal activation, which enabled a dehydrative cross-coupling process to occur under mild reaction conditions. This reaction worked in an environmentally friendly manner, yielding water as the only byproduct. A variety of allylic sulfones could be obtained in good to excellent yields with wide functional group tolerance. In gram scale reactions, allylic sulfones could be conveniently isolated in high yield by filtration.

Allyl sulfone compound and preparation method and application thereof

The invention discloses an allyl sulfone compound and a preparation method and application thereof. The preparation method comprises the following steps of sequentially adding allyl alcohol, sulfinicacid, palladium tetrakis(triphenylphosphine) and calcium bis(trifluoromethylsulfonyl)imide into a reaction solvent in an inert gas atmosphere, and carrying out a reaction under stirring for 12-48 h atthe temperature of 30 DEG C, wherein the equivalent ratio of allyl alcohol, sulfinic acid, palladiumtetrakis(triphenylphosphine) and calcium bis(trifluoromethylsulfonyl)imide is 1: (1.5-2): (1-3%): (5-10%); and removing the reaction solvent in the reaction liquid, and then performingpurifying to obtain the allyl sulfone compound. The preparation method disclosed by the invention is high in economy and wide in applicable substrate range; in addition, the obtained allyl sulfone compound has potential pharmaceutical activity and biological activity and is an important skeleton widely existing inbiologically and pharmaceutically active molecules.