16215-12-6

Basic information

• Product Name: 4-chlorophenyl 2-phenylvinyl sulfone
• Synonyms: 4-chlorophenyl 2-phenylvinyl sulfone;1-chloro-4-{[(E)-2-phenylethenyl]sulfonyl}benzene
• CAS NO: 16215-12-6
• Molecular Formula: C₁₄H₁₁ClO₂S
• Molecular Weight: 278.75394
• Mol File: 16215-12-6.mol
• Article Data: 48

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chlorophenyl 2-phenylvinyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorophenyl 2-phenylvinyl sulfone(16215-12-6)
• EPA Substance Registry System: 4-chlorophenyl 2-phenylvinyl sulfone(16215-12-6)

Safety Data

• Hazardous Substances Data: 16215-12-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 40137-12-0 diethyl<<(p-chlorophenyl)sulfonyl>methyl>phosphonate 
• 100-42-5 styrene 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 66680-87-3 (E)-1-phenyl-(2-tributylstannyl)ethene 
• 32228-21-0 (E)-(styryl)(4-chloro-phenyl)sulfide 
• 3405-89-8 2-(4-chloro-phenylsulfonyl)acetic acid 
• 92150-69-1 1-chloro-4-((phenylethynyl)sulfonyl)benzene 
• 932-88-7 1-iodo-2-phenylethyne 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 69770-58-7 diethyl<<(p-chlorophenyl)sulfide>methyl>phosphonate 
• 3405-88-7 (4-chlorophenylthio)acetic acid 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 536-74-3 phenylacetylene 

Downstream Products

• 1097725-23-9 methyl 4-(4-chlorophenylsulfonyl)-3-phenylbutyrate 
• 40582-90-9 p-chlorophenyl 2-phenylhexyl sulfone 

Relevant articles and documents

Intermolecular [2 + 2] Photocycloaddition of α,β-Unsaturated Sulfones: Catalyst-Free Reaction and Catalytic Variants

2-Aryl-1-sulfonyl-substituted cyclobutanes were prepared in an intermolecular [2 + 2] photocycloaddition from various α,β-unsaturated sulfones and olefins upon irradiation at λ = 300 nm (26 examples, 60-99% yield). Lewis acids catalyzed the [2 + 2] photocycloaddition of 2-benzimidazolyl styryl sulfones. At short wavelengths, the latter substrates underwent C-S bond cleavage but AlBr3 (5 mol %) allowed for an intermolecular reaction with 2,3-dimethyl-2-butene at longer wavelengths. A chiral-at-metal Lewis acid (2 mol %) facilitated an enantioselective reaction (up to 77% ee).

Cu-catalyzed dehydrogenative olefinsulfonation of Alkyl arenes

A copper-catalyzed reaction protocol for the dehydrogenation of ethylbenzenes into styrene derivatives has been developed. This reaction procedure proceeded well under mild reaction conditions, providing a practical and efficient strategy for the rapid assembly of biologically and pharmaceutically significant molecules, such as vinyl sulfone. Simple alkyl arenes were functionalized via consecutive β-elimination in the presence of N-sulfonylbenzo[d]imidazole with broad substrate scope and good functional group tolerance.