162272-48-2

Upstream product

• 133382-26-0 (E)-2-cyanocinnamate of (S)-ethyl lactate 
• 106-99-0 buta-1,3-diene 

Downstream Products

• 1026501-96-1 (1S,2R)-1-Cyano-2-phenyl-cyclohexanecarbonyl azide 
• 162272-57-3 Methyl (1R,2R)-1-isocyanato-2-phenyl-1-cyclohexanecarboxylate 
• 162272-55-1 Methyl (1S,2R)-1-(aminocarbonyl)-2-phenyl-1-cyclohexanecarboxylate 
• 1026878-49-8 (1S,2R)-1-Cyano-2-phenyl-1-cyclohexanecarboxylic acid chloride 
• 162272-51-7 (1S,2R)-1-Cyano-2-phenyl-1-cyclohexanecarboxylic acid 
• 165674-42-0 Methanesulfonic acid (1S,2R)-1-cyano-2-phenyl-cyclohexylmethyl ester 
• 165674-43-1 (1R,2R)-1-Azidomethyl-2-phenyl-cyclohexanecarbonitrile 
• 165674-38-4 (1S,6R)-methyl 1-cyano-6-phenyl-3-cyclohexene-1-carboxylate 
• 165674-39-5 (1S,2R)-methyl 1-aminomethyl-2-phenyl-1-cyclohexanecarboxylate 
• 165674-40-8 (1S,2R)-1-hydroxymethyl-2-phenyl-1-cyclohexanecarbonitrile 
• 165674-44-2 (1R,2S)-1-aminomethyl-2-phenyl-1-cyclohexanecarbonitrile 
• 162272-56-2 Methyl (1S,2R)-1-cyano-2-phenyl-1-cyclohexanecarboxylate 
• 162272-50-6 (1S,6R)-1-Cyano-6-phenyl-3-cyclohexene-1-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of a new type of conformationally constrained α,α-disubstituted-β-amino acids and β-lactams in enantiomerically pure form

Optically active cis-, 8a and 8b, and trans-1-aminomethyl-2-phenylcyclohexane-1-carboxylic acids, 9a and 9b, were obtained starting from 1,3-butadiene using Diels-Alder cycloadditions with chiral (E)-2-cyanocinnamates as key steps and following a protocol

Asymmetric Diels-Alder Reactions of Chiral (E)-2-Cyanocinnamates. 2. Synthesis of the Four 1-Amino-2-phenyl-1-cyclohexanecarboxylic Acids in Enantiomerically Pure Form

High and complementary diastereoselectivities were obtained in the asymmetric Diels-Alder reactions of chiral (E)-2-cyanocinnamates with butadiene when (S)-ethyl lactate and (R)-pantolactone were used as chiral auxiliaries in the presence of TiCl4.The mos