1629159-61-0Relevant academic research and scientific papers
Chemodivergent synthesis of multi-substituted/fused pyrroles via copper-catalyzed carbene cascade reaction of propargyl α-iminodiazoacetates
Zhang, Cheng,Chang, Sailan,Qiu, Lihua,Xu, Xinfang
, p. 12470 - 12473 (2016)
A novel cascade reaction of alkynyl-tethered α-iminodiazoacetates has been developed, which provides a general access to both multi-substituted and fused pyrroles in high yields with a broad substrate scope. The γ-imino carbene is proposed as the key intermediate in this divergent reaction and followed by unpresented transformations.
Visible-light-induced formal [3+2] cycloaddition for pyrrole synthesis under metal-free conditions
Xuan, Jun,Xia, Xu-Dong,Zeng, Ting-Ting,Feng, Zhu-Jia,Chen, Jia-Rong,Lu, Liang-Qiu,Xiao, Wen-Jing
, p. 5653 - 5656 (2014/06/10)
A photocatalytic formal [3+2] cycloaddition of 2H-azirines with alkynes has been achieved under irradiation by visible light in the presence of organic dye photocatalysts. This transformation provides efficient access to highly functionalized pyrroles in good yields and has been applied to the synthesis of drug analogues. A primary trial of photocascade catalysis merging energy transfer and redox neutral reactions was shown to be successful. Photo(chemistry) op: A photocatalytic formal [3+2] cycloaddition of 2H-azirines with alkynes has been established under the irradiation of visible light in the presence of an organic dye. This transformation provides efficient access to highly functionalized pyrroles in good yields and has been applied to the formal synthesis of an inhibitor for HMG-CoA reductase.
