16331-64-9

Basic information

• Product Name: 1-hydroxyethyl radical
• Synonyms: 1-hydroxyethyl radical
• CAS NO: 16331-64-9
• Molecular Formula: C₂H₅O
• Molecular Weight: 0
• EINECS: 200-849-9
• Mol File: 16331-64-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 72.6°Cat760mmHg
• Flash Point: 8.9°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 1-hydroxyethyl radical(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxyethyl radical(16331-64-9)
• EPA Substance Registry System: 1-hydroxyethyl radical(16331-64-9)

Safety Data

• Hazardous Substances Data: 16331-64-9(Hazardous Substances Data)

Usage

Structure

Radical structure

Reactivity

Highly reactive

Formation

Formed during the metabolism of ethanol in the human body

Role in the body

Involved in the oxidation and processing of alcohol in the liver

Interaction with biological molecules

Can react with various biological molecules

Potential consequences

Leading to potential cellular damage

Implication in health issues

Linked to the development of alcohol-induced liver injury and other alcohol-related health consequences

Importance in research

Reactivity and potential for harm make it an important area of study in biochemistry and toxicology

InChI:InChI=1/C2H5O/c1-2-3/h2-3H,1H3

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 62268-73-9 diphenylcarbene 
• 54128-17-5 trifluoromethanide 
• 3938-95-2 2,2-dimethyl-propanoic acid ethyl ester 
• 3315-60-4 methanolate 
• 141-78-6 ethyl acetate 
• 82765-40-0 (Z)-(2-chloro-5-nitrophenyl)azo ethyl ether 
• 71099-80-4 C₈H₈ClN₃O₃ 
• 71099-79-1 C₈H₈ClN₃O₃ 
• 71099-77-9 C₉H₁₁N₃O₃ 
• 62375-92-2 C₈H₉N₃O₃ 
• 82765-38-6 (Z)-(2,5-dichlorophenyl)azo ethyl ether 

Downstream Products

• 36264-66-1 1,1,1',1'-tetramethoxy-2,6,2',6'-tetraphenyl-4,4'-ethoxymethanediyl-bis-1λ⁵-phosphinine 
• 858675-60-2 2-ethoxy-6-fluoropyridine 
• 100-42-5 styrene 
• 64-17-5 ethanol 
• 21438-99-3 cyanomethanide 
• 31139-07-8 propargyl anion 
• 93-89-0 benzoic acid ethyl ester 
• 22113-51-5 p-cresolate 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 14609-74-6 p-nitrophenolate 
• 20227-79-6 3-methylphenolate anion 
• 18938-14-2 3-chlorophenoxide 
• 24573-38-4 4-chlorophenolate 
• 94-08-6 4-methylbenzoic acid ethyl ester 

Related news

Interaction of 1-hydroxyethyl radical (cas 16331-64-9) with Antioxidant Enzymes08/06/2019

There is considerable interest in the role of the 1-hydroxyethyl radical (HER) in the toxic effects of ethanol. The goal of this study was to evaluate the effects of HER on classical antioxidant enzymes. The interaction of acetaldehyde with hydroxylamine-o-sulfonic acid has been shown to produce...detailed

Interaction of 1-hydroxyethyl radical (cas 16331-64-9) With Glutathione, Ascorbic Acid and α-Tocopherol08/05/2019

Ethanol has been shown to be oxidized to a free radical metabolite, the 1-hydroxyethyl radical (HER). Interaction of HER with cellular antioxidants may contribute to the known ability of ethanol administration to lower levels of GSH and α-tocopherol. Experiments were carried out to establish a ...detailed

Relevant articles and documents

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KINETIC ISOTOPE EFFECT IN GAS-PHASE BASE-INDUCED ELIMINATION REACTIONS

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Gas-Phase Nucleophilic Displacement Reactions

Displacement reactions of each of a variety of anionic nucleophiles reacting with each of a variety of neutrals have been studied by pulsed ion cyclotron resonance (ICR) spectroscopy.Rate constants for these reactions are interpreted in terms of a three-step reaction sequence.RRKM calculations are used to obtain information about the energy of transition states.The origin of the barrier to reaction in solution is discussed.

Trimethylphosphine: Anion-Molecule Reactions and Acidity in the Gas Phase

Gas-phase acidity of trimethylphosphine has been investigated at ambient temperature by examining proton-transfer reactions in 40 Pa of helium buffer gas in a Flowing Afterglow instrument.On the basis of the occurence-non-occurence of a number of proton-transfer reactions and the observation of rapid H-D exchange between D2O and the conjugate base of trimethylphosphine, it has been determined that trimethylphosphine is more acidic than water.Quantitative measurements are reported for the reaction of trimethylphosphine with atomic oxygen anion and methoxide.These latter two anions exhibit multiple reaction pathways, one of which is proton transfer.From measurements of the rate coefficients of these two reactions and the relative product yields, it is concluded that the gas-phase acidity of trimethylphosphine is very similar to that of the hydroxyl radical; the recommended value is ΔGoacid(PMe3) 1577 +/- 13kJ mol-1.The derived acidity measurement is in slight contrast to recent theoretical and experimental estimates.Furthermore, it is found that anions which react only slowly with trimethylphosphine by proton transfer can undergo an alternative reaction which corresponds to addition of the neucleophilic anion to trimethylphosphine followed by loss of methane.