16347-96-9Relevant academic research and scientific papers
Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones
Hu, Baoxiang,Zhang, Xiaochu,Sheng, Lili,Guo, Ming,Shen, Zhenlu,Hu, Xinquan,Sun, Nan,Mo, Weimin
, p. 5580 - 5593 (2013/07/04)
A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.
One-pot etherification of purine nucleosides and pyrimidines
Kokatla, Hari Prasad,Lakshman, Mahesh K.
supporting information; experimental part, p. 4478 - 4481 (2010/12/24)
A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and pyrimidinones is described. Exposure of the heterocycle to 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and Cs2CO3/s
