16347-97-0

Basic information

• Product Name: 4-phenoxyquinazoline
• Synonyms: 4-Phenoxyquinazoline; Phenyl 4-quinazolinyl ether
• CAS NO: 16347-97-0
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.242
• Mol File: 16347-97-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 372.6°C at 760 mmHg
• Flash Point: 135.7°C
• Density: 1.23g/cm³
• Vapor Pressure: 2.04E-05mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 4-phenoxyquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenoxyquinazoline(16347-97-0)
• EPA Substance Registry System: 4-phenoxyquinazoline(16347-97-0)

Safety Data

• Hazardous Substances Data: 16347-97-0(Hazardous Substances Data)

Upstream product

• 5190-68-1 4-chloroquinazoline 
• 108-95-2 phenol 
• 897930-10-8 4-(1H-benzo[d][1,2,3]triazol-1-yloxy)quinazoline 
• 98-80-6 phenylboronic acid 
• 1276665-99-6 C₈H₅Cl₅N₅OP₃ 
• 1003015-89-1 4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)quinazoline 
• 491-36-1 4-Hydroxyquinazoline 

Downstream Products

• 15018-66-3 4-Aminoquinazoline 
• 3476-68-4 Glycorin 
• 100537-42-6 4-phenoxy-quinazoline-1-oxide 
• 100537-56-2 1-hydroxy-4-phenoxy-1H-quinazolin-2-one 
• 41229-10-1 4-(piperidin-1-yl)-quinazoline 
• 108-95-2 phenol 
• 7505-81-9 2-methylaminobenzamide 
• 491-36-1 4-Hydroxyquinazoline 

Relevant articles and documents

Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones

A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.

Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids

Pyridotriazol-1-yloxypyrimidine 3 reacts with arylboronic acids under palladium-free, Cs2CO3, (0.8%) H2O2, and DME conditions to produce heteroaryl ethers 4-16 in good yields comparable to the oxidative palladiu

The scope and mechanism of phosphonium-mediated SNAr reactions in heterocyclic amides and ureas

(Chemical Equation Presented) An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed. Treatment of cyclic amides and ureas with benzotriazol-l-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), base, and nitrogen nucleophiles leads to the formation of the corresponding cyclic amidines and guanidines, typically in good to excellent yields. This method has also been used to prepare heteroaryl ethers and thioethers using phenol and thiophenol nucleophiles. Time course NMR and HPLC-MS studies have facilitated explicit characterization of the proposed intermediates (the phosphonium salt and HOBt adduct); the data reveal a stepwise reaction pathway.