16351-47-6

Upstream product

• 591-50-4 iodobenzene 
• 16986-24-6 1,7-dicarba-closo-dodecaborane⁽¹²⁾ 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 7647-01-0 hydrogenchloride 
• 23704-65-6 1-(Hg-m-CB₁₀H₁₀CC₆H₅)-7-(C₆H₅)-1.7-C₂B₁₀H₁₀x 
• 74315-34-7 1-[Ir(H)(Cl)(CO)(PPh3)2]-7-C6H5-1,7-(σdicarba-closo-dodecaborane(12)) 
• 74333-17-8 1-[Ir(H)(I)(CO)(PPh3)2]-7-C6H5-1,7-(σdicarba-closo-dodecaborane(12)) 
• 74333-17-8 1-[Ir(H)(I)(CO)(PPh3)2]-7-C6H5-1,7-(σdicarba-closo-dodecaborane(12)) 
• 74333-16-7 1-[Ir(H)(Br)(CO)(PPh3)2]-7-C6H5-1,7-(σdicarba-closo-dodecaborane(12)) 
• 74315-34-7 1-[Ir(H)(Cl)(CO)(PPh3)2]-7-C6H5-1,7-(σdicarba-closo-dodecaborane(12)) 
• 23883-32-1 1-(HgCl)-7-(C₆H₅)-1.7-C₂B₁₀H₁₀ 
• 64-17-5 ethanol 

Downstream Products

• 26603-14-5 (CH₃)3Sn-1,7-B₁₀C₂H₁₀C₆H₅ 
• 778595-97-4 1-mercapto-7-phenyl-meta-carborane anion 
• 153984-81-7 1-phenyl-2-(2-pyridyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾ 
• 265987-35-7 1,7-PhCB₁₀H₁₀CC₆F₅ 
• 265987-36-8 1,4-(m-PhCB₁₀H₁₀C)2C₆H₄ 
• 778595-96-3 1-hydroxy-7-phenyl-meta-carborane anion 
• 1621595-85-4 1-(4-cyanophenyl)-7-phenyl-1,7-dicarba-closo-dodecaborane 

Relevant academic research and scientific papers

The organic electroluminescent element material and using the material of the organic electroluminescent element

Provided are: an organic electroluminescent element (organic EL element) having improved element light emission efficiency, ensuring sufficient drive stability, and having a simple configuration; and a material for organic EL elements, used in same. This

Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C′-diphenylcarborane scaffold as a hydrophobic pharmacophore

The progesterone receptor (PR) plays important roles in multiple physiological processes, including female reproduction. Here, we report the synthesis of nonsteroidal PR antagonists containing a boron cluster as the hydrophobic core. We found that 1,7-diphenyl-meta-carborane was the preferred substructure among the three carborane isomers. Compound 39 was the most potent PR antagonist (IC50: 29 nM). Compound 41 also exhibited potent activity (IC50: 93 nM), and did not bind to androgen receptor, glucocorticoid receptor or mineralocorticoid receptor. These compounds may be useful for investigating potential clinical applications of PR modulators.

Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols

The lipase-catalyzed asymmetric acetylation of secondary alcohols containing a carborane (boron cluster) moiety was investigated. Most lipases examined showed poor catalytic activity toward carborane-containing secondary alcohol 1a, but lipase TL efficiently catalyzed the acetylation of 1a with high enantioselectivity, to afford (R)-3a. This selectivity is similar to that of the general lipase-catalyzed acylation of secondary alcohols. Utilizing lipase TL, we succeeded in the resolution of carborane-containing alcohol 5, synthesized as a progesterone receptor ligand candidate, and evaluated the activities of the two enantiomers.

C-arylation and C-heteroarylation of icosahedral carboranes via their copper(I) derivatives

Reaction between C-mono- or C,C'-di-copper(I) derivatives of 1,2- 1,7-, or 1,12-dicarba-closo-dodecaborane(12) and aryl iodides in the presence of pyridine gives the corresponding C-mono- or C,C'-diaryl derivatives of 1,7- and 1,12-dicarba-closo-dodecaboranes(12); 1,2-dicarba-closo-dodecaborane(12) gives only the C-monoaryl product.Cyclic or linear arylene coupled systems are obtained when di-iodoarenes are used.Copper(I) derivatives may be generated from C-unsubstituted or C-monosubstituted carboranes using copper(I) t-butoxide when substituents incompatible with the use of C-lithio-intermediates are involved.The C-copper(I) derivative of 1,2-dicarba-closo-dodecaborane(12) gives 1,2-di-2'-pyridyl-1,2-dicarba-closo-dodecaborane(12) specifically with 2-bromopyridine.The (inferred) intermediate mono-2-pyridyl-derivative, obtained independently from 2-ethynylpyridine and the dimethylsulphide complex of decaborane, gives 1-phenyl-2,2'-pyridyl-1,2-dicarba-closo-dodecaborane(12) upon conversion into its copper(I) derivative and treatment with iododobenzene.However, the copper(I) derivative of 1-phenyl-1,2-dicarba-closo-dodecaborane(12) does not react to a significant extent with 2-bromopyridine.

Carborane reductive-elimination reaction from a six-coordinate hydridocarboranyliridium(III) complex: Kinetic and mechanistic study

A kinetic and mechanistic study of the reductive-elimination reaction of the carborane 1-H-T-C6H5-1,7-C2B10H10 (H-carb) from the six-coordinate iridium(III) complex Ir(H)(Cl)(σ-carb)(CO)(PPh3)2 has been carried out in 1,2-dichloroethane by IR spectroscopy between 20 and 50°C. The mechanism of the carborane-elimination reaction implies a preliminary PPh3 dissociation to give the five-coordinate Ir(H)(Cl)(σ-carb)(CO)(PPh3) complex. This intermediate then undergoes a reductive elimination of the carborane molecule through two pathways: (i) direct elimination to give the three-coordinate iridium(I) complex, IrCl(CO)(PPh3); (ii) a phosphine-induced elimination via trans → cis isomerization of the H and carb ligands. The kinetic and thermodynamic parameters are also reported and discussed.